Today's News and Commentary

 About pharma

Greater Access to New Weight Loss Meds Could Save More Than 40,000 Lives Per Year “Making the drugs available to all obese people and overweight type 2 diabetics could save more than 42,000 American lives annually.”
About 45% of the U.S. adult population is eligible to take the weight-loss drugs by those standards.”

Why Does an $84,000 Drug in the U.S. Cost Less Than $1,000 in India An excellent article in Forbes reviews the relevant issues.

About healthcare IT

100M people impacted by massive Change Healthcare cyberattack: OCR “UnitedHealth Group has officially disclosed that 100 million people were affected by the massive cyberattack on Change Healthcare earlier this year.” 

About healthcare finance

AbbVie inks $1.4B Aliada buyout, landing ex-J&J Alzheimer's drug to leap the blood-brain barrier “AbbVie has agreed to pay $1.4 billion to buy Aliada Therapeutics. The acquisition will give AbbVie control of an Alzheimer’s disease drug candidate Aliada in-licensed from Johnson & Johnson to try to improve on the first generation of anti-amyloid-beta antibodies.
Aliada is developing an antibody that binds to pyroglutamate amyloid beta, a form of the peptide found in the brains of people with Alzheimer’s.”

Today's News and Commentary

About health insurance/insurers

1 million+ patients lose coverage as insurers, hospitals drop Medicare Advantage “…this year, as Medicare’s open enrollment season kicks off, more than 1 million patients will have to shop for new health insurance. Facing financial and federal regulatory pressures, many insurers are pulling their Medicare Advantage plans from counties and states they’ve deemed unprofitable. Meanwhile, large health systems in states including Alabama, Minnesota and Vermont have cut ties with some Medicare Advantage plans.”

Doc groups target alleged center of insurers' price-fixing 'cartel' in lawsuit “The American Medical Association and the Illinois State Medical Society say MultiPlan, a data analytics agency for health plans, is at the center of a price-fixing "cartel" with commercial health insurers.
In a lawsuit filed yesterday in U.S. District Court for the Northern District of Illinois, the Chicago-based associations say New York-based MultiPlan has undercut fair payment for out-of-network health care services and eliminated market competition.”

About hospitals and healthcare systems

The only 17 hospitals to earn Magnet's top honor FYI

  About health technology

Baxter International to restart highest-throughput IV solutions manufacturing line next week “Initial batches will be manufactured concurrently with ongoing quality activities and would only be released in accordance with applicable regulatory requirements to ensure the quality and safety of the products, the company said on its hurricane update page Thursday.” 

Today's News and Commentary

About health insurance/insurers

Medicare Advantage: Questionable Use of Health Risk Assessments [HRA] Continues To Drive Up Payments to Plans by Billions What OIG Found
Diagnoses reported only on enrollees’ HRAs and HRA-linked chart reviews, and not on any other 2022 service records, resulted in an estimated $7.5 billion in MA risk-adjusted payments for 2023.
The lack of any other followup visits, procedures, tests, or supplies for these diagnoses in the MA encounter data for 1.7 million MA enrollees raises concerns that either: (1) the diagnoses are inaccurate and thus the payments are improper or (2) enrollees did not receive needed care for serious conditions reported only on HRAs or HRA-linked chart reviews.
In-home HRAs and HRA-linked chart reviews generated almost two-thirds of the estimated $7.5 billion in risk-adjusted payments. In-home HRAs and HRA-linked chart reviews may be more vulnerable to misuse because these tools are often administered by MA companies or their third-party vendors and not enrollees’ own providers. Diagnoses reported only on these types of records heighten concerns about the validity of the diagnoses or the coordination of care for MA enrollees.
Just 20 MA companies drove 80 percent of the estimated $7.5 billion in payments. Also, these MA companies generated a substantially greater share of payments resulting from HRAs or HRA-linked chart reviews for certain health conditions, including serious and chronic illnesses, such as diabetes and congestive heart failure.”
UnitedHealth Group accounted for $3.7 billion of the questionable payments. See the full report as well.

CMS lifts enrollment suspension on UnitedHealthcare Medicare Advantage plan “CMS has lifted an enrollment suspension on a UnitedHealthcare subsidiary's Medicare Advantage plan following three years of not meeting the required 85% medical loss ratio.”

Results from an Annual Medicaid Budget Survey for State Fiscal Years 2024 and 2025 Exerpted highlights from this KFF report:
”PROVIDER RATES AND MANAGED CARE
--States had implemented (in FY 2024) and were planning (in FY 2025) a wide range of fee-for-service (FFS) rate increases across provider types and very few states were implementing rate restrictions. More than half of states (26 states) reported increasing both inpatient and outpatient hospital FFS base rates in FY 2024, and many states reported increases in both hospital FFS base rates and total non-DSH supplemental payments.
--About two-thirds of responding MCO states (25 of 41) reported seeking CMS approval for a capitation rate amendment to address shifts in the average risk profile (or “acuity”) of MCO members in FY 2024 and/or FY 2025.
BENEFITS AND PRESCRIPTION DRUGS
--Most states continue to implement benefit enhancements, particularly for mental health and/or substance use disorder (SUD) services.  and mortality and addressing racial/ethnic health disparities.
--Twelve state Medicaid programs reported covering GLP-1s (glucagon-like peptide-1s) when prescribed for the treatment of obesity, under FFS as of July 1, 2024.
SOCIAL DETERMINANTS OF HEALTH AND REDUCING HEALTH DISPARITIES
--A number of states are expanding or enhancing Medicaid coverage to help address enrollee social determinants of health (SDOH) or associated health-related social needs (HRSN). 
--States are implementing strategies to reduce racial and ethnic health disparities, including through changes in managed care contracts. 
--States may also tie MCO financial quality incentives to reducing health disparities. About one-third of states reported at least one MCO financial incentive tied to reducing racial/ethnic disparities in place in FY 2024, most commonly linking capitation withholds or pay for performance incentives to improving health disparities.”

About hospitals and healthcare systems

Celebrating Excellence: Healthgrades Names Leading Hospitals for Specialty Care in 2025  FYI.

Sanford, Marshfield Clinic to create 56-hospital system “The integration is expected to close by the end of 2024, with the parties remaining separate, independent organizations ahead of closing.” 

About pharma

Thousands of bottles of popular antidepressant recalled “Thousands of bottles of a popular antidepressant medication are being recalled due to the presence of what the National Library of Medicine describes as a toxic chemical, according to a notice from the U.S. Food and Drug Administration.
The recall involves the medication duloxetine, which is sold under the brand name Cymbalta, according to the FDA's notice of the voluntary recall, which began Oct. 10.”

About the public’s health

In boon for Pfizer and Merck, CDC panel backs expanded use of pneumococcal vaccines “In a 14-1 vote, the panel moved to expand its usage recommendation for both Pfizer’s Prevnar 20 and Merck’s Capvaxive to include all adults aged 50 and older as well as adults between 19 and 49 years of age with certain risk factors. Previously, the broad recommendation for PCV shots was for those older than 65.” 

About healthcare finance

General Catalyst:Announcing Fund XII “Today, we are announcing that we have raised approximately $8B of new capital, including around $4.5B for our core VC funds focused on seed and growth equity (across our Ignition, Endurance, and Health Assurance strategies), $1.5B for our Creation strategy, and $2B of separately managed accounts. As a global investment company that seeks to partner with the world’s most ambitious entrepreneurs to drive transformation, resilience, and applied AI, we believe this capital will turbocharge our investment theses across AI, Defense & Intelligence, Climate & Energy, Industrials, Healthcare and Fintech.” 

Today's News and Commentary

About health insurance/insurers

Social Determinants of Health [SDoH] and US Health Care Expenditures by Insurer “This cross-sectional study found individual-level SDOH to be significantly associated with US health care expenditures, potentially incentivizing health insurers to utilize SDOH in their decision-making practices to identify and control expenditures. Health insurers may use HRSN [health-related social needs]to identify beneficiaries at greater risk for high expenditures to target interventions by prioritizing SDOH domains found to be significant in our analysis. Addressing structural SDOH may require insurers to engage with multisectoral stakeholders with shared funding mechanisms and for public policymakers to adopt a health-in-all policies approach. While addressing HRSN may be more feasible in the short term, targeting structural SDOH through multisectoral partnerships may address the root cause to achieve a more equitable and sustainable health care system.”

Medicaid Enrollment & Spending Growth: FY 2024 & 2025 Key survey findings include the following:

  • Following years of significant growth, Medicaid enrollment declined by -7.5% in FY 2024 and state Medicaid officials expect enrollment to continue to decline by -4.4% in FY 2025. These growth rates reflect the net Medicaid enrollment change from year to year including new enrollments, coverage losses due to unwinding, and some “churn” when those who lose coverage re-enroll within a short period of time. The unwinding of the continuous enrollment provision was the largest driver of enrollment declines. [Emphasis added]

  • Total Medicaid spending growth slowed to 5.5% in FY 2024 and is expected to slow further to 3.9% in FY 2025. While state Medicaid officials identified unwinding-related enrollment declines as the most significant factor driving changes in total Medicaid spending, they also noted a number of upward pressures on total spending. This included enrollment increases from eligibility changes such as 12-month continuous eligibility for children or overall state or Medicaid eligible population growth, the higher health care needs of enrollees that retained coverage during unwinding, and rate increases.

  • As anticipated, state Medicaid spending growth increased sharply in FY 2024 (19.2%) as the enhanced FMAP phased down and expired (after declining earlier in the pandemic despite high enrollment growth). State Medicaid spending growth is projected to slow to 7.0% in FY 2025, only slightly higher than total spending growth as the shifts caused by the enhanced FMAP expiration end.” 

About pharma

Walmart plans to deliver prescriptions nationwide in as little as 30 minute “Walmart's new service includes new prescriptions and refills, which customers can receive along with groceries and other products, the Bentonville, Arkansas-based company announced on Tuesday. Prescriptions will be delivered in as little as 30 minutes and should be available for over 86% of American households, according to Walmart.”
In a related article:  Walmart and Amazon threaten US drugstores in prescription delivery 

About the public’s health

FDA approves 1st RSV vaccine for adults under 60 “The FDA approved Pfizer's Abrysvo, the first and only RSV vaccine for adults aged 18 to 59 who are at increased risk of severe respiratory illness caused by RSV.” 

About healthcare IT

Transparency has led to uniformity in healthcare costs—but not necessarily lower prices: study “Price transparency regulations are leveling the cost landscape for consumers, but that doesn’t always lead to lower prices, according to a new report from Turquoise Health…
 Since the regulations were established, and adjusting for inflation, the top 25% of prices fell by 6.3%. However, the bottom 25% of prices increased by 3.4%. Meanwhile, the middle 50% of prices decreased just 1.1%. Turquoise analyzed prices at 232 hospitals across the 10 largest U.S. metro areas to track changes across market segments, from December 2021 to June 2024.” 

About healthcare personnel

Clinician Staffing and Quality of Care in US Health Centers “In this cross-sectional study of health centers, physician FTE ratio was associated with higher performance in cancer screening, infant vaccinations, and HIV testing; APRN FTE ratio was associated with higher performance in preventative health assessments; and PA FTE ratio was associated with higher performance in infant vaccination. These findings suggest that targeted staffing strategies may be associated with quality of care in certain domains and that tailored approaches to health center staffing based on community-specific needs are warranted.”  

Today's News and Commentary

About health insurance/insurers

More kids lacked health insurance in 2023, Census Bureau finds “Ninety-two percent of U.S. adults were insured in 2023, according to ‘Health Insurance Coverage in the United States: 2023,’ one in a series of bureau reports released in September. The rate of adults who lacked insurance held steady at about 8% —approximately 26.4 million people.
The uninsured rate for children rose, however, jumping from 5.4% in 2022 to 5.8%, with about 4.4 million children lacking coverage in 2023. Coverage fell for children of all races and ethnicities, but dropped the most among Hispanic children, 9.4% of whom lacked insurance last year. About 4.8% of Black children were uninsured, as were 4.4% of white children and 4.2% of Asian children.
Kids in states that had not expanded Medicaid eligibility were uninsured at about twice the rate of those that had expanded.”

Biden-Harris Administration’s Inflation Reduction Act Saves Medicare Enrollees Nearly $1 Billion in Just the First Half of 2024 “Today , the Department of Health and Human Services (HHS), through the Office of Assistant Secretary for Planning and Evaluation (ASPE), released new data showing that nearly 1.5 million people with Medicare Part D saved nearly  $1 billion in out-of-pocket prescription drugs costs in the first half of 2024 because of the Biden-Harris Administration’s Inflation Reduction Act. Thanks to the Inflation Reduction Act, some people with high drug costs have their out-of-pocket drug costs capped at around $3,500 in 2024. Next year that cap lowers to $2,000 for everyone with Medicare Part D. The report shows that if the $2,000 cap had been in effect this year, 4.6 million enrollees would have hit the cap by June 30 and would not have to pay any more out-of-pocket costs for the rest of the year.” 

About pharma

2023 340B Covered Entity Purchases “In calendar year 2023, 340B covered entities purchased $66.3 billion in covered outpatient drugs under the 340B Program.”
See the document for a breakdown of where the money went by institutional type.

Amid backlash, FDA changes course over shortage of weight-loss drugs “The U.S. Food and Drug Administration, after intense public pressure and a lawsuit, is reconsidering its declaration barely two weeks ago that a shortage of the appetite-suppressing drugs Mounjaro and Zepbound is over, a temporary about-face that will allow pharmacies to keep selling unbranded copies.”

Vertex details non-opioid drug data from acute pain trials ahead of FDA verdict “Vertex Pharmaceuticals' experimental acute pain drug suzetrigine (VX-548) demonstrated fewer adverse events (AEs) than both placebo and standard opioid therapy, possibly setting a new benchmark for non-opioid pain management as the company nears its January 30 FDA decision date.”

About the public’s health

National Trends in Infant Mortality in the US After Dobbs “Infant mortality was higher than expected, overall and among those with congenital anomalies, for several months after the Dobbs decision in the US. No post-Dobbs months (ie, no months after June 2022) showed lower than expected infant mortality. These findings are consistent with the increase in infant mortality found in Texas following the state’s abortion ban.” 

Today's News and Commentary

About health insurance/insurers

Cigna Resumes Merger Discussions with Humana After Talks Ended Last Year “The two health insurance giants, with a combined market value of more than $125 billion, have held informal discussions recently about a potential deal, said the people who asked to not be identified because the talks aren’t public. The discussions are in early stages, they added.
Shares of Humana were up 5.6% after the close of regular trading Friday, while Cigna fell about 5.3%…
Cigna is looking to close the sale of its Medicare Advantage business in the coming weeks before committing to any other transactions, one of the people said. That exit could help pave the way for a deal with Humana by removing areas of overlap that would draw scrutiny from antitrust regulators.”

Why Do Health Insurers Keep Getting Slammed With Higher Costs? “The surge in Medicaid costs may go beyond just a mismatch between reimbursement rates and patient health. As is already the case in Medicare, we could be seeing the start of a broader rise in healthcare expenses as more low-income Americans seek treatment for a variety of conditions, many worsened by the pandemic. For example, both UnitedHealth and Elevance have reported higher behavioral health costs in their Medicaid programs. It has been well documented that low-income Americans experience higher rates of mental-health issues, and the pandemic likely exacerbated this trend.”

Refusal of Recovery: How Medicare Advantage Insurers Have Denied Patients Access to Post-Acute Care “On May 17, 2023, the Permanent Subcommittee on Investigations (“PSI” or “the Subcommittee”) launched an inquiry into the barriers facing seniors enrolled in Medicare Advantage in accessing care…
Among the Subcommittee’s new findings:

• Between 2019 and 2022, UnitedHealthcare, Humana, and CVS each denied prior authorization requests for post-acute care at far higher rates than they did for other types of care, resulting in diminished access to post-acute care for Medicare Advantage beneficiaries.
o In 2022, both UnitedHealthcare and CVS denied prior authorization requests for post- acute care at rates that were approximately three times higher than the companies’ overall denial rates for prior authorization requests. In that same year, Humana’s prior authorization denial rate for post-acute care was over 16 times higher than its overall rate of denial.
PSI also obtained internal documents that provide insight into each company’s use of the prior authorization, including the role of automation and predictive technologies.”
Comment: Read the entire summary and look at Figure 1 on page 19.

About pharma

The Powerful Companies Driving Local Drugstores Out of Business “Obscure but powerful health care middlemen — companies known as pharmacy benefit managers, or P.B.M.s — [have destroyed local pharmacy businesses].”
This has been happening all over the country, a New York Times investigation found. P.B.M.s, which employers and government programs hire to oversee prescription drug benefits, have been systematically underpaying small pharmacies, helping to drive hundreds out of business.
The pattern is benefiting the largest P.B.M.s, whose parent companies run their own competing pharmacies. When local drugstores fold, the benefit managers often scoop up their customers, according to dozens of patients and pharmacists.”

Biden's proposed rule change for over-the-counter birth control coverage “The Biden administration is proposing rules that would require insurers to cover the costs of over-the-counter contraceptives without a prescription.”

About the public’s health

Tobacco Product Use Among Middle and High School Students — National Youth Tobacco Survey, United States, 2024 “From 2023 to 2024, current (previous 30-day) use of any tobacco product declined among high school students from 12.6% to 10.1%, largely driven by the decline in high school e-cigarette use (from 10.0% to 7.8%). During 2024, e-cigarettes remained the most commonly used tobacco product among U.S. youths; nicotine pouches were the second most commonly used tobacco product.” 

About health technology

Baxter aims to import 18K tons of product: 6 IV shortage updates “Baxter International is responding to critical IV supply shortages affecting patients after Hurricane Helene disrupted its North Cove manufacturing facility, which produces 60% of the U.S. IV fluid market's supply. 
With the situation growing urgent, Baxter is importing 18,000 tons of essential products to alleviate these shortages by the end of the year, according to an Oct. 17 news release from the company.”  

Today's News and Commentary

 About pharma

Weight loss surgery more cost effective than GLP-1s: Study “The long-term cost-effectiveness of GLP-1s versus bariatric surgery has been a looming unknown in the healthcare industry. Gastric bypass and sleeve gastrectomy operations typically cost between $17,400 and $22,850. In contrast, the average annual cost of GLP-1s is between $9,360 and $16,200, but the ideal duration of GLP-1 regimens has not been established. 
After analyzing the costs of these treatments until death (up to 50 years) and clinical trial efficacy findings for thousands of patients, the researchers uncovered two main findings. 
First, bariatric surgery added two quality-adjusted life years and saved patients about $9,000 more each year compared to GLP-1s. Second, combining surgery and GLP-1s led to more benefits, with average savings of about $7,200 a year and five additional quality-adjusted life years compared to surgery alone. 
For GLP-1s alone to achieve similar cost-effectiveness, their prices need to drop by about 75%, according to Joseph Sanchez, MD, the study's lead author. “

About the public’s health

Tobacco Product Use Among Middle and High School Students — National Youth Tobacco Survey, United States, 2024 “From 2023 to 2024, current (previous 30-day) use of any tobacco product declined among high school students from 12.6% to 10.1%, largely driven by the decline in high school e-cigarette use (from 10.0% to 7.8%). During 2024, e-cigarettes remained the most commonly used tobacco product among U.S. youths; nicotine pouches were the second most commonly used tobacco product.” 

About healthcare IT

UnitedHealth, CVS and Humana increasingly deploy AI and deny post-acute care claims, Senate report finds “The country’s three largest Medicare Advantage (MA) insurers obstruct seniors’ ability to receive post-acute care, a scathing report from the U.S. Senate Permanent Subcommittee on Investigations shows.
It outlines attempts from UnitedHealthcare, CVS and Humana—which collectively cover nearly 60% of all MA enrollees—to use technology to reject prior authorization claims, all while reaping profit.
Between 2019 and 2022, the three insurers denied claims for post-acute care at “far higher” rates than for other types of care, and, in 2022, Humana denials in post-acute care were 16 times higher than the companies’ overall denial rates, the report (PDF) says. UnitedHealthcare and CVS denials were three times higher in the same year.”

Solera Health Study Suggests Virtual Healthcare Networks Can Reduce the Cost of Care by up to 3.1% “Conducted in conjunction with healthcare machine-learning company Health at Scale, the research demonstrated that strategically shifting site of care from in-person care to virtual creates a potential 2.3-3.1% reduction in total medical claims spend. Based on Centers for Medicare & Medicaid Services (CMS) estimates of private insurer expenditures in 2022, that could yield a U.S. cost savings of $37 billion to over $50 billion annually.”

Today's News and Commentary

About health insurance/insurers

Elevance posts $1B profit in Q3, lowers earnings forecast “Elevance Health posted $1 billion in net income during the third quarter, a 21% decrease compared to the same period last year, according to the company's earnings report published Oct. 17.
The company lowered its full-year earnings outlook from $37.20 in net income per diluted share to $33.”

About hospitals and healthcare systems

Is Hospital Market Concentration Related to Medical Debt? While medical debt on credit reports declined across most US counties between 2012 and 2022, increases in hospital market concentration prevented such improvements in many areas of the country.
We find that counties that experienced larger increases in hospital market concentration, as measured by the Herfindahl-Hirschman Index (HHI), experienced smaller declines in the share of residents with medical debt. The correlation between a county’s change in medical debt and its HHI is 0.2. For comparison, this correlation is similar in magnitude to that observed between a county’s medical debt and its racial and ethnic makeup but is a weaker correlation than that between a county’s medical debt and its health insurance coverage rates and chronic disease prevalence.” 

About pharma

Wave Clinical Trial Shows First Successful RNA Editing in Humans “Wave Life Sciences said today its alpha-1 antitrypsin deficiency (AATD) candidate WVE-006 succeeded in the first-ever clinical demonstration of RNA editing in humans by achieving positive proof-of-mechanism in an early-phase clinical trial.” 

Why hundreds of US pharmacies are closing Changing consumer trends and market dynamics are leading to hundreds of pharmacy store closures in the U.S.
Brick-and-mortar locations are losing to mail-order and digital options, according to a J.D. Power study of pharmacy customers. Between 2023 and 2024, overall customer satisfaction in physical drug stores declined 10 points on a 1,000-point scale, and satisfaction scores for mail-order pharmacies increased six points.”

About healthcare IT

Early Warning Scores With and Without Artificial Intelligence Findings  In this cohort study that compared 6 early warning scores across 362 926 patient encounters, eCARTv5, a machine learning model, identified clinical deterioration best with an area under the receiver operating characteristics curve (AUROC) of 0.895 and the highest positive predictive values at both the moderate- and high-risk matched thresholds. The National Early Warning Score, a non–artificial intelligence score with an AUROC of 0.831, was the second-best performer at both thresholds, while the Epic Deterioration Index was one of the worst, with an AUROC of 0.808 and the lowest positive predictive values.
Meaning  Given the wide variation in accuracy, these findings suggest that additional transparency and oversight of early warning tools may be warranted.”

Change Healthcare cyberattack costs to reach $2.87B “UnitedHealth estimated the company would absorb about an additional 10 cents a share in costs for the February ransomware attack that disrupted claims processing and breached patient data across the nation, bringing the total to 75 cents a share, according to a third-quarter earnings report.
The healthcare conglomerate now estimates it will take a $2.87 billion hit from the cyberattack in 2024, after originally anticipating $1.6 billion in costs.”

Today's News and Commentary

About health insurance/insurers

Best Insurance Companies for Medicare Advantage in 2025 FYI from US News.

About hospitals and healthcare systems

Hospital operating margins to stay low in 2025: Moody's “‘Hospital labor costs rocketed over the last four years, hitting margins and cash flow hard, according to Moody's. And the problem isn't going away any time soon.
‘The steep rise in healthcare wages over the last three years remains a structural problem and credit risk for the hospital industry,’ states Moody's Oct. 15 report on hospital financial performance. ‘While the wage growth rate will remain low in 2025, average hourly earnings will continue to top prior years. Reimbursement increases from payors, particularly government ones will not keep up with higher wages.’
Moody's noted the median operating cash flow margin was 8.5% for nonprofit hospitals in 2019, before the pandemic, and dropped since then to 5.3% in 2023. Growing expenses in labor and supply costs are driving the change, with salaries and benefits comprising 53% of nonprofit hospitals' expenses, according to Moody's. Supply costs comprise 21% of the expenses, based on 2023 medians.”

About pharma

As IV shortage continues after hurricane, U.S. invokes wartime power to speed recovery “The Biden administration says it has invoked the wartime powers of the Defense Production Act to speed rebuilding of a major American factory of intravenous fluids that was wrecked by Hurricane Helene last month. Damage to the plant in North Carolina has worsened a nationwide shortage of IV fluids, and hospitals say they are still postponing some surgeries and other procedures as a result. 
Some 60% of the nation's IV supplies had relied on production from the plant, run by medical supplier Baxter, before it was damaged by the storm.”

Teva adopts biotech ethos as it leans into innovative drug development, exec says “Amid a reorganization campaign that’s breathed new life into hybrid generic and innovative medicines player Teva, the company is leaning into novel medicines and formulations more than ever and adopting a biotech mindset as it pushes a range of assets through the clinic.”
Comment: Over the years, Teva has changed from a generic manufacturer to developer of innovative drugs. This history is unusual in the field. 

Independent Pharmacies Reluctant to Stock Drugs in Medicare Negotiation Program, New Survey Shows “A new national survey shows more than 90 percent of independent pharmacists may not sell drugs for which the Medicare Part D program is trying to negotiate lower prices.”

About healthcare IT

Why health systems are reducing virtual visits “While 8 in 10 health systems offer at least the same amount of virtual care as two years ago, the rest either stopped or are providing fewer virtual visits, according to the Deloitte Center for Health Solutions.
Here are the top reasons health systems reduced or discontinued virtual care, according to the consultant's survey of 51 healthcare executives released Oct. 16.
1. Physician and clinician team preference for using virtual health appears low: 60%   
2. Don't need to take COVID-19 precautions anymore: 60%
3. Interest in virtual care among patients appears low or most patients want to be in person: 40%
4. Changes to payment incentives or lack of adequate reimbursement to organizations: 30%”

Today's News and Commentary

About health insurance/insurers

Medicare annual enrollment begins “The Medicare annual enrollment period has begun, marked by significant changes in the Medicare Advantage market.
Among these changes are increased government scrutiny, tighter CMS regulations, reduced base payments, and rising healthcare costs among older adults.
In response to these market shifts, many MA carriers are prioritizing their margins over membership by reducing certain benefits and exiting unprofitable markets. As margins tighten and negotiations with providers become more strained, some providers are choosing to no longeraccept some or all MA plans.”
See, also: Changes in store for Medicare Advantage as open enrollment starts

Healthcare Premiums Are Soaring Even as Inflation Eases, in Charts “The cost of employer health insurance rose 7% for a second straight year, maintaining a growth rate not seen in more than a decade, according to an annual survey by the healthcare nonprofit KFF. The back-to-back years of rapid increases have added more than $3,000 to the average family premium, which reached roughly $25,500 this year.
Employers spent about $1,880 more this year, bringing their average cost for family premiums to $19,276. Workers’ share of the average family premium dropped by roughly $280 from last year, to $6,296.”

Blue Cross antitrust lawsuit reaches $2.8B tentative settlement “The Blue Cross Blue Shield Association and its 33 member companies will pay $2.8 billion and change the way they operate under a tentative settlement reached with a collection of providers.
The multipronged settlement would end a 12-year legal battle concerning allegations that the companies and the Chicago-based nonprofit association violated the Sherman Antitrust Act of 1890 by colluding to suppress competition and lower reimbursements. It also would change the companies’ BlueCard Program system for dealing with out-of-network patients.”

UnitedHealth beats the Street with $6B in Q3 profit “UnitedHealth Group kicked off another round of earnings calls for major health insurance companies Tuesday morning, when it reported $6.06 billion in profit for the third quarter of 2024.
That's up slightly from the $5.8 billion the company posted in the third quarter of 2023. However, UnitedHealth has brought in $8.9 billion in profit through the first three quarters of the year, down by close to half from the $16.9 billion reported through the first nine months of 2023…
UHG said that its Optum Health and Optum Rx units led the charge on growth in the third quarter.”

About hospitals and healthcare systems

National Hospital Flash Report “Key Takeaways
1. August data show relatively stable margins. Patient volume has increased, but once adjusted for volume, revenue and expenses have also declined.
2. Average length of stay is trending down. This development indicates less severe patient acuity and efficient care transition pathways.
3. On a volume-adjusted basis, expenses show a slight decline. While expenses are still high compared to previous years, the growth rate is slowing down.”

About pharma

Walgreens to close 1,200 stores: 6 things to know “Walgreens will close around 1,200 retail stores over three years, including around 500 closures in fiscal year 2025, according to its earnings report for the 2024 fiscal year ended Aug. 31.
The company shared plans in June to close ‘a significant portion’ of its underperforming stores in late June due to financial difficulties and ongoing environmental pressures.”

Pharmacist gets up to 15 years in prison for Michigan meningitis outbreak deaths “A Massachusetts pharmacist was sentenced Friday in Michigan to 7 1/2 to 15 years in prison for his role in a 2012 national meningitis outbreak that killed dozens of people…
He already is serving a 10 1/2-year federal sentence for racketeering, fraud and other crimes connected to the outbreak, following a 2017 trial in Boston. The Michigan sentence also will be served in federal prison. He will get more than 6 1/2 years of credit for time already served.
Chin supervised production at the New England Compounding Center in Framingham, Massachusetts, which shipped steroids for pain relief to clinics across the country. Investigators said the lab was rife with mold and insects.”

Recent Trends in Medicaid Outpatient Prescription Drugs and Spending “Key findings include:

  • The number of Medicaid prescriptions each year was on the decline until FY 2020 when the trend reversed; however, the number of prescriptions only increased by 3% overall from FY 2017 to FY 2023 and the number of prescriptions per enrollee declined.

  • At the same time, net spending (spending after rebates) on Medicaid prescription drugs is estimated to have increased by 72%, from $30 billion in FY 2017 to $51 billion in FY 2023, likely driven by the emergence of new high-cost specialty drugs.

  • Rebates reduce Medicaid spending on prescription drugs by over half, but the decrease is larger for fee-for-service (FFS) drug spending.”


About the public’s health

US COVID levels drop, with few flu detections “For COVID, test positivity has declined to 7.7% nationally, but is a little higher in the Western region that includes the Dakotas, Montana, Wyoming, Colorado, and Utah. Emergency department visits for COVID continue to decline. Hospitalizations remain on a downward trend. Deaths also declined, though CDC provisional data show 424 people died from their COVID infections last week…
For flu, activity is still at the low level, and of the few viruses reported by public health labs last week, 55.8% were the 2009 H1N1 strain and 42.2% were H3N2, the CDC in its latest weekly FluView report.”

About health technology

Deep learning AI model scans 'dark matter' of genomic data to find 70,000 never-before-seen RNA viruses “Some of the 161,979 viruses the team sequenced were so different from other RNA viruses that they could form 180 new separate supergroups. Holmes said finding a new supergroup is similar to finding a new phylum of animals—meaning some of these viruses are as different from each other as crabs are to earthworms or cats are to jellyfish.” 

Today's News and Commentary

About hospitals and healthcare systems

4 hospital expansions worth $1B or more FYI. Costly expansions are still occurring

 About pharma

India’s copycat drugmakers gear up to offer cheaper weight-loss drugs It was only a matter of time…
And in a related story: In win for compounders, FDA will review its decision to put Eli Lilly's tirzepatide on shortage list 

About healthcare IT

Average ransom payments rise for healthcare: 6 notes “In 2024, the percentage of healthcare organizations paying ransomware demands decreased to 36%, down from 40% in 2023. However, those that did comply faced steeper costs, an Oct. 8 survey from Proofpoint and Ponemon Institute found.”
For example: “The average ransom rose by 10% to $1,099,200, compared to $995,450 in 2023.”

About healthcare personnel

The rising cost of physician subsidies in 10 numbers “The median physician subsidy increased in the second quarter while the gap between primary care and surgical specialists widened, according to data from Kaufman Hall's Physician Flash Report.
Fort examples:
—”The median loss per full time provider, including advanced practitioners, hit $232,145 in the second quarter, up from $225,072 over the same period last year.
—Average loss per full time provider for primary care practitioners hit $150,000 while loss per surgical specialist provider hit $294,000.”

Today's News and Commentary

About health insurance/insurers

Medicare Advantage star ratings decline: 5 things to know “Average Medicare Advantage star ratings declined for the third year in a row, according to CMS data published Oct. 10.”
For example:
 “Just seven plans received a five-star rating in 2025, down from 38 in 2024.
Around 40% of Medicare Advantage-Part D plans received four stars or higher. Around 62% of MA-PD enrollees are in plans rating four or higher, according to CMS.”
Here is more information from CMS. Of note is that “There were no major methodological changes in the 2025 Star Ratings. Minor methodological changes were included for 2025, such as increasing the weight for the Part C Plan All-Cause Readmissions measure from one to three.”

About hospitals and healthcare systems

FTC finalizes premerger rule: 9 things to know  The article provides a good summary of the key provisions of the rule. Click here to read the 460-page rule in full. 

Site-of-care shifts 2024: Inside the latest trends and data  From The Advisory Board: “Following several years of outpatient and ASC eligibility, joint replacement volumes shifted to majority outpatient. The COVID pandemic disrupted volume trends and created a clinical impetus to minimize inpatient utilization. Operational changes solidified outpatient shifts, while care practices changed across service lines, resulting in structural changes to care delivery. As we’ve seen in past analyses, local forces including the physician landscape, infrastructure, volumes and health plan activity shape the pace of change.”
Most changes are from inpatient to hospital outpatient department.

About pharma

Competition in International Generic Drug Markets “The US and Germany appeared most competitive based on the metrics analyzed, while smaller countries tended to seem less competitive. This is consistent with previous findings that market size is associated with generic competition.
Despite more manufacturers recording generic sales in most countries since 2010, the present results had potentially concerning implications in the context of increasing drug shortages, a problem that has gained increasing attention over the past decade and is now considered a crisis. Market concentration remained intractably high in all countries in 2022, meaning that supply disruptions may cause patients to switch therapies or forego treatment for a large share of drugs sold in all countries. While drug shortages are complex phenomena and caused by multiple factors, policy efforts to strengthen competition (eg, incentivizing market entry of new manufacturers and deterring market dominance) could strengthen access to medicines.”

About the public’s health

Milton spares Daytona Beach, Florida, factory that’s a critical supplier of IV fluids “B. Braun Medical’s manufacturing site and distribution center in Daytona Beach were not seriously impacted by the hurricane, said company spokesperson Allison Longenhagen. No injuries to employees have been reported.
The company, with help from the federal government, had moved more than 60 truckloads of IV solutions inventory north of Florida before the storm. Longenhagen said that will they will be returned to the distribution site.
The federal Administration for Strategic Preparedness and Response helped coordinate trucks and drivers for the temporary move, which involved nearly 1.5 million bags of solution, a representative said Thursday.”
And in a related article:
US approves temporary imports of IV fluids as hospitals grapple with storm-related shortages “Federal health officials have approved the import of certain IV fluids from overseas as hospitals across the country scramble to deal with a Hurricane Helene-inflicted shortage…
A survey from group purchasing organization Premier Inc. found that more than 86 percent of health care providers are experiencing shortages of IV fluids in the aftermath of Helene. Shortages were evenly spread nationwide, across all provider types.” 

About healthcare IT

Microsoft expands AI capabilities to shape a healthier future “On Thursday, Microsoft Corp. [unveiled] several Microsoft Cloud for Healthcare innovations that connect care experiences, enhance team collaboration, empower healthcare workers, and unlock clinical and operational insights.
Through new healthcare AI models in Azure AI Studio, capabilities for healthcare data solutions in Microsoft Fabric, the healthcare agent service in Copilot Studio, and an AI-driven nursing workflow solution, Microsoft Cloud for Healthcare is supporting healthcare organizations on every step of their journey toward shaping a healthier future.”

Today's News and Commentary

About pharma

Amazon Pharmacy plans to expand Same-Day Delivery of medications to nearly half the US in 2025 “Amazon Pharmacy plans to open pharmacies in 20 new cities across the U.S. in 2025, more than doubling the number of cities where customers can get Same-Day Delivery of their medications.” 

Drug Maker Teva Pharmaceuticals Agrees to Pay $450M in False Claims Act Settlement to Resolve Kickback Allegations Relating to Copayments and Price Fixing “Teva Pharmaceuticals USA Inc. (Teva USA) and Teva Neuroscience Inc. (collectively, Teva) have agreed to pay $450 million to resolve two matters that allege Teva violated the Anti-Kickback Statute (AKS) and the False Claims Act (FCA). Teva, headquartered in Parsippany, New Jersey, is the largest generic drug manufacturer in the United States. The settlement amount was based on Teva’s ability to pay.”
Read the announcement for more detail of the case. 

Payments by Drug and Medical Device Manufacturers to US Peer Reviewers of Major Medical Journals “More than half of the 1962 US physicians included in this study who peer reviewed for the most influential medical journals received industry payments in 2020-2022, with most payments for research. Research payments, especially those provided to an institution, may have different implications than general payments for conflicts of interest. Peer reviewers in this study received $64.18 million in general payments between 2020 and 2022, representing a median general payment of $7614, larger than the median general payment to all physicians in 2018 of $216.”

About the public’s health

One in Seven Children Meet WHO Healthy Behavior Guidelines “Globally, most 3- and 4-year-old children do not meet the current World Health Organization (WHO) guidelines for physical activity, sedentary behavior, and sleep, according to a study published online Sept. 30 in JAMA Pediatrics.
Kar Hau Chong, Ph.D., from University of Wollongong in Australia, and colleagues examined the proportion of 3- and 4-year-old children who met the WHO guidelines for physical activity, sedentary behavior, and sleep across 33 countries. The researchers included a pooled analysis of data from 14 cross-sectional studies (7,017 children; July 2008 to September 2022) identified through systematic reviews and personal networks…
 Africa had the highest proportion meeting the guidelines (23.9 percent), while North and South America had the lowest proportion (7.7 percent).” 

Baxter bringing back hurricane-hit IV supply facility in stages “Baxter International is bringing its hurricane-hit IV manufacturing facility in North Carolina back online in stages, with a goal of restoring 90% to 100% of customer needs by the end of the year, the company said on Wednesday…
The site makes 60% of the nation's supply of IV fluids and peritoneal dialysis solutions, or 1.5 million bags daily, according to the American Hospital Association.”

Today's News and Commentary

About health insurance/insurers

2024 Employer Health Benefits Survey This annual KFF report is the best source for data on the employer-sponsored health benefit market.
In a related article: Health Benefits In 2024: Higher Premiums Persist, Employer Strategies For GLP-1 Coverage And Family-Building Benefits “In 2024, the average annual premium for employer-sponsored family health coverage was $25,572, an increase of $1,604 (7 percent) from 2023. Over the course of the past five years, the average family premium has increased 24 percent, which is similar to growth seen in inflation (23 percent) and wages (28 percent). On average, covered workers contributed 16 percent ($1,368) of the cost of single coverage and 25 percent ($6,296) of the cost of family coverage. The average general annual deductible for single coverage for workers with a deductible was $1,787, similar to that in recent years but 47 percent higher than a decade ago. In 2024, 18 percent of large firms offering health benefits, including 28 percent of those with 5,000 or more employees, covered GLP-1 antagonists for weight loss. Large employers were more likely to perceive their overall provider networks as broader than their networks for mental health and substance use conditions.”

ACA Provision Linked to Improved Survival in Young Adult Cancer Patients “After the Dependent Care Expansion was enacted, the cancer death rate declined more rapidly among patients who were 19-25 years of age than among those who were 12-18 years or 26-32 years of age.”

Healthcare billing fraud: 12 recent cases FYI. All are results of a fee-for-service system’s incentives.

About pharma

GSK dodges courtroom showdown with $2.2B Zantac settlement “GSK has agreed to pay up to $2.2 billion to resolve some 80,000 US state court cases related to its discontinued heartburn medication Zantac (ranitidine) and its alleged links to cancer. The settlement announced on Wednesday covers 93% of the pending Zantac-related cases against GSK in US state courts.”

Medicare $2 Drug List Model – Request for Information (RFI) – Responses Due December 9, 2024 “The Innovation Center’s Medicare $2 Drug List Model proposes testing whether a simplified approach to offering low-cost, clinically important generic drugs can improve medication adherence, lead to better outcomes, and improve beneficiary and prescriber satisfaction with the Part D benefit.”
The RFI has a list of proposed medications. 

About healthcare IT

Nobel Prize in Chemistry awarded to 3 scientists for predicting and designing proteins “The Nobel Prizes are embracing the AI hype. A day after the Physics prize was given to two scientists for foundational work on machine learning, the Nobel Prize in Chemistry has been awarded to three scientists who used advanced computational methods to solve a decades-old problem: understanding how proteins fold together into three-dimensional shapes.
Half of the 2024 Chemistry prize goes to David Baker, Ph.D., “for computational protein design” while the other half is split between Demis Hassabis, Ph.D., and John Jumper, Ph.D., “for protein structure prediction.”  

Evaluating the use of large language models to provide clinical recommendations in the Emergency Department “Here, we conduct a highly-powered study to determine whether LLMs can provide clinical recommendations for three tasks (admission status, radiological investigation(s) request status, and antibiotic prescription status) using clinical notes from the Emergency Department. We randomly selected 10,000 Emergency Department visits to evaluate the accuracy of zero-shot, GPT-3.5-turbo- and GPT-4-turbo-generated clinical recommendations across four different prompting strategies. We found that both GPT-4-turbo and GPT-3.5-turbo performed poorly compared to a resident physician, with accuracy scores 8% and 24%, respectively, lower than physician on average. Both LLMs tended to be overly cautious in its recommendations, with high sensitivity at the cost of specificity.” [Emphasis added]

Today's News and Commentary

About hospitals and healthcare systems

Best Children’s Hospitals by Specialty  U.S. News just issued its annual ranking.

 About pharma

Novo Nordisk, Mylan settle generic Ozempic dispute A potential future thorn in Novo Nordisk's side was preemptively removed this month after the Danish drugmaker reached a settlement with Mylan Pharmaceuticals and Natco Pharma over a generic version of its blockbuster diabetes drug, Ozempic (semaglutide). 
Even though Ozempic isn't set to lose patent exclusivity in the US until 2032, Novo initiated a patent infringement lawsuit against Mylan, now part of Viatris, over a year ago.”

Compounders sue FDA for removing Eli Lilly's tirzepatide from shortage list “With an estimated 2 million people in the United States taking copycat versions of Eli Lilly and Novo Nordisk’s incretin hormone drugs, compounding pharmacies have suddenly thrived from their ability to help meet the booming demand for these products.
But last week, when the FDA removed Lilly’s tirzepatide from its drug shortage list, it erased the compounders’ qualification to manufacture one of their two new cash cows.”
Comment: The only reason compounders were allowed to make those products was an exception in case of FDA declared shortages.

IQVIA Global Oncology Trends 2024: Outlook to 2028 Key findings:

  • Cancer incidence is expected to rise significantly through 2050, particularly in lower-income countries, potentially increasing by more than 12 million new cases annually to 32 million.

  • Global spending on cancer medicine increased to $223 billion in 2023, $25 billion more than 2022, and is projected to reach $409 billion by 2028.

  • In 2023, 25 oncology novel active substances (NASs) were launched globally, making a total of 193 since 2014 – however, large geographic variations exist in availability of these medicines.

  • More than 2,000 new oncology clinical trials started in 2023 with novel modalities and significant promise for cancer treatment, including cell and gene therapies, antibody-drug conjugates, multispecific antibodies, and radioligand therapies.

  • Cancer treatments have increased 9% annually since 2019 but the pace of bringing novel therapies to patients is uneven due to differences in biomarker testing rates, adoption of novel therapies and lack of infrastructure capacity to deliver some of the most advanced therapies.

About the public’s health

In landmark move, EPA requires removal of all U.S. lead pipes in a decade “The Environmental Protection Agency finalized a rule Tuesday requiring water utilities to replace all lead pipes within a decade, a move aimed at eliminating a toxic threat that continues to affect tens of thousands of American children each year.
The move, which also tightens the amount of lead allowed in the nation’s drinking water, comes nearly 40 years after Congress determined that lead pipes posed a serious risk to public health and banned them in new construction.”

Supreme Court declines to intervene in Texas emergency abortion case “The Supreme Court on Monday refused to require doctors in Texas to perform certain emergency abortions when the procedure would conflict with the state’s strict abortion ban.
The justices left in place a lower-court ruling that rejected the Biden administration’s claim that federal law requires access to emergency abortion care even in states that restrict the procedure.”

U.S. Supreme Court won’t hear appeal from Alabama IVF clinics “The U.S. Supreme Court Monday declined to review an Alabama case that sparked a national debate over the availability of in vitro fertilization (IVF) treatments. 
The Center for Reproductive Medicine and Mobile Infirmary Medical Center filed a petition in August challenging a  February Alabama Supreme Court ruling that frozen embryos were minor children under an 1872 law. 
The decision forced several clinics to temporarily halt services and sparked widespread criticism. The Alabama Legislature in March approved a bill granting clinics criminal and civil immunity in the course of providing IVF treatments.”

About healthcare IT

California to require physician oversight of AI-driven health insurance decisions “The bill establishes requirements for health plans using AI or other software tools for utilization review and management decisions. The tools must rely on a patient's medical and clinical history and not override provider decisions — any violations could result in legal consequences. The bill also prohibits AI, algorithms, or software tools from making decisions based solely on group data or discriminating against patients in violation of state or federal laws. Tools must also be open for audit or compliance reviews.”

John Hopfield and Geoffrey Hinton awarded Nobel Prize in physics “The academy honored Hinton, a computer scientist, and Hopfield, a physicist, “for foundational discoveries and inventions that enable machine learning with artificial neural networks.” While the laureates have made waves in computer science, their work relies on physics principles.”  

Today's News and Commentary

Trilliant Health’s 2024 Trends Shaping the Health Economy: Macro Edition  “KEY TAKEAWAYS

  • Health status for Americans continues to decline, especially for younger Americans. Mortality remains higher than pre-pandemic, with the largest increase in the 18-44 age group.

  • Early onset cancers are rising, with higher volumes of patients ages 45 and younger for breast (+6.6%), colon (+10.0%), kidney (+2.1%) and uterine (+16.0%) cancers from Q4 2018 to Q4 2023.

  • GLP-1s have surpassed insulin to become the second most common medication for type 2 diabetes, rising from the eighth most common drug regimen in 2018.

  • Actual usage for clinical artificial intelligence (AI) remains low, with only 202K patients across all AI CPT codes between 2018 and 2023.”

About health insurance/insurers

Heard on the Street: Humana Could Plunge Into Cigna’s Arms “When Cigna considered a tie-up with Humana last year, Humana was worth about $60 billion. That made it a sizable target for Cigna, whose market value was then about $80 billion. Cigna eventually walked away after shareholders balked at the deal.
Now, a merger is looking a lot more palatable. Cigna, which is focused on the commercial insurance market and has therefore avoided headwinds in the Medicarebusiness, has seen its stock continue to gain, as Humana has struggled. Cigna is now worth nearly $100 billion, while Humana’s market capitalization has sunk to about $27 billion.
Humana shares were down 13% Wednesday midday, due to recent changes to the government’s quality ratings that could eat into the company's bonus payments. The insurer warned that fewer of its plans would be rated four stars or above, hitting profits in 2026.”

CONGRESSIONAL BUDGET OFFICE Report to the House Ways and Means Committee about the effect of Medicare Part D Changes. Was the result of this action unintended or just caused by stupidity? “After accounting for information about 2025 bids from plans that provide coverage under Part D, CBO expects that the additional plan costs reflected in those bids will result in an increase in federal spending of $10 billion to $20 billion in calendar year 2025, compared with our earlier projections.
CBO also estimates that the temporary subsidies will increase federal spending in calendar year 2025 by an additional $5 billion and that, over the next decade, this will lead to an increase of $2 billion in net spending for interest, relative to prior projections.”

About hospitals and healthcare systems

One or Two Health Systems Controlled the Entire Market for Inpatient Hospital Care in Nearly Half of Metropolitan Areas in 2022 Key Takeaways

  • One or two health systems controlled the entire market for inpatient hospital care in nearly half (47%) of metropolitan areas in 2022.

  • In more than four of five metropolitan areas (82%), one or two health systems controlled more than 75 percent of the market.

  • Nearly all (97% of) metropolitan areas had highly concentrated markets for inpatient hospital care when applying HHI thresholds from antitrust guidelines to MSAs.”

Hospitals prepare for monthslong supply disruptions after Helene, port strike “The healthcare industry is facing significant supply chain challenges that are starting to disrupt essential services. Between the temporary Baxter North Cove plant closure and the East and Gulf Coast port strikes, hospitals are beginning to feel the impact, raising concerns about the availability of critical intravenous solutions and other essential medical supplies.”

Acute Hospital Care at Home Reports An excellent CMS report on this topic. 

About the public’s health

Arm Position and Blood Pressure Readings “Findings  This crossover randomized clinical trial of 133 adults showed that supporting the arm on the lap overestimated systolic BP by 3.9 mm Hg and diastolic BP by 4.0 mm Hg. An unsupported arm at the side overestimated systolic BP by 6.5 mm Hg and diastolic BP by 4.4 mm Hg, with consistent results across subgroups.
Meaning  Commonly used, nonstandard arm positions during BP measurements substantially overestimate BP, highlighting the need for standardized positioning.”
Comment: The standard position is the arm resting on a desk. Make sure that your BP is tested that way when you next have it checked.

'Good business and good health go hand in hand': Reducing inequities could add $2.8T to GDP by 2040, Deloitte finds “Improving health equity could add $2.8 trillion to the U.S. gross domestic product by 2040, Deloitte found, and, for U.S.-based businesses, corporate profits could increase by $763 billion. Businesses could also see improved workforce participation (people who would no longer be leaving due to premature death and disability) and productivity (rates of absenteeism and presenteeism).” 

About healthcare IT

2024-2030 Federal Health IT Strategic Plan An excellent document laying out governmental plans and reasons for their implementation.

Black Book IT Leader Survey Reveals 8 Technologies Draining Value From Health Systems “Over 900 healthcare technology experts identified key data systems that fail to deliver ROI and siphon funds from providers after implementation. In 2024, U.S. respondents reported that compounding inefficiencies, system downtimes, and ineffective health IT integration have driven total industry losses to over $8 billion annually, a sharp increase from $1.7 billion in 2017.”

 About health technology

Nobel Prize in physiology or medicine awarded for discovery of microRNA “American scientists Victor Ambros and Gary Ruvkun won the 2024 Nobel Prize in physiology or medicine Monday for the discovery of microRNAs, a class of tiny molecules that have been connected to heart disease, a wide variety of cancers and viral diseases.
Mutations in microRNAs, just like those in genes, can lead to diseases, and fixing or replacing mutant microRNAs may prove crucial to developing treatments.
Ambros and Ruvkun figured out that these small molecules have the power to reduce or block production of proteins, responsible for virtually every human action from breathing to thinking.
Not to be confused with messenger RNA — which acts as a “middleman” in the process of translating genetic material into proteins — microRNAs add a crucial, previously unrecognized layer to the process. MicroRNAs can bind on to the messenger RNA and are able to help cells regulate the kinds and amounts of proteins that are made.”

FDA APPROVES EXACT SCIENCES’ COLOGUARD PLUS™ TEST, SETTING A NEW BENCHMARK IN NON-INVASIVE COLORECTAL CANCER SCREENING “FDA approval was based on findings from the pivotal BLUE-C study, one of the largest prospective, head-to-head studies ever conducted in CRC screening. Among the subset of nearly 19,000 average-risk participants, the Cologuard Plus test demonstrated 95% overall cancer sensitivity and 43% sensitivity for advanced precancerous lesions at 94% specificity with no findings on colonoscopy. Results from BLUE-C also show the Cologuard Plus test significantly outperformed an independent fecal immunochemical test (FIT) for overall CRC sensitivity, treatable-stage CRC (stages I-III) sensitivity, high-grade dysplasia sensitivity, and advanced precancerous lesion sensitivity.”

About healthcare finance

Activist investor Starboard builds $1bn stake in drugmaker Pfizer “Activist investor Starboard Value has built a $1bn position in Pfizer, according to two people familiar with the matter, as the drugmaker behind the top-selling Covid-19 jab struggles to reverse a fall in its share price to below pre-pandemic levels. Starboard is seeking a turnaround of Pfizer, according to the two people. It has taken the stake as investors question the New York-based drugmaker’s path to post-pandemic growth after its Covid-19 vaccine delivered a shortlived bump in revenues that waned faster than expected. Pfizer’s market value stood at $161bn as of Friday, after a 52 per cent drop from its pandemic peak. Its shares have traded flat this year, while the S&P 500 has risen by about 20 per cent.”

Today's News and Commentary

Five Things to Know: Healthcare and the U.S. Election A great summary from Gallup. One takeaway is that 2/3 of all Americans think healthcare should get more attention in the election.

About pharma

Prescription Medication Use, Coverage, and Nonadherence Among Adults Age 65 and Older: United States, 2021–2022 “In 2021–2022, 88.6% of older adults took prescription medication,
82.7% had prescription drug coverage, 3.6% did not get needed prescription medication due to cost, and 3.4% did not take medication as prescribed due to cost. Older adults with no prescription drug coverage were more likely to not get prescription medication and to not take needed medication as prescribed than older adults with private or public prescription drug coverage. For both measures, cost-related nonadherence was six times higher among older adults who were food insecure compared with those who were food secure, and more than twice as likely among older adults reporting fair or poor health or with disabilities compared with those in excellent, very good, or good health, or without disabilities.”

CVS board conducting strategic review, mulling breakup: report “CVS Health is conducting a strategic review of options, including possibly breaking up the company, as it faces headwinds to its retail business and its insurance operation, Aetna, sources told the The Wall Street Journal on Monday.
The healthcare company's board of directors retained bankers to facilitate the review, WSJ reported, citing sources with knowledge of the matter. No decision is imminent and it's possible there won't be changes to CVS' business, the sources said.” 

About the public’s health

Outbreak of Whooping Cough Hitting Vaccinated Kids and Parents “The US is in the midst of the biggest pertussis outbreak in a decade, with 15,661 cases and two deaths reported this year through the middle of September. That rate is five times higher than a year ago, when cases were already on the rise following the end of Covid-19 pandemic restrictions that suppressed transmission of all respiratory infections.” 

Today's News and Commentary

About health insurance/insurers

Medicare Advantage and Medicare Prescription Drug Programs to Remain Stable as CMS Implements Improvements to the Programs in 2025 “Centers for Medicare & Medicaid Services (CMS) announced that average premiums, benefits, and plan choices for Medicare Advantage (MA) and the Medicare Part D prescription drug program will remain stable in 2025. Average premiums are projected to decline in both the MA and Part D programs from 2024 to 2025. Enhancements adopted in the 2025 MA and Part D Final Rule, as well as payment policy updates in the 2025 MA and Part D Rate Announcement, support this stability and increase enrollee protections and access to care for people with Medicare.” 

About pharma

J&J to forgo 340B rebate plan implementation “Johnson & Johnson has decided to terminate implementation of its 340B rebate plan, according to an internal email 340B Health shared with Becker's.
In late August, the drugmaker planned to replace upfront 340B discounts with a rebate plan.
The Health Resources and Services Administration notified J&J that it would initiate proceedings to terminate the company's participation unless it halts its 340B rebate policy, which the agency said violates federal law, according to a Sept. 27 news release.”
 

About the public’s health

U.S. Preterm Births Are on the Rise “Over the past decade, rates of preterm birth in the United States jumped more than 10%, a new study of more than 5 million births shows.
The rise dovetailed with an increase in some factors that make an early delivery more likely, including rates of diabetes, sexually transmitted infections and mental health conditions, along with a corresponding decline in factors that protect against it.
Meanwhile, racial and economic disparities persist.”  

About healthcare IT

HEALTHCARE RANSOMWARE ATTACKS CONTINUE TO INCREASE IN NUMBER AND SEVERITY “Across all industry sectors, the number of organizations that reported suffering a ransomware attack in the past 12 months fell from 66% in 2023 to 59% in 2024. Sophos surveyed 402 healthcare organizations, and 67% said they had experienced a ransomware attack in the past 12 months, up from 60% the previous year, and on a par with the 66% that experienced ransomware attacks in 2022.”

Today's News and Commentary

About health insurance/insurers

A Snapshot of Sources of Coverage Among Medicare Beneficiaries KEY HIGHLIGHTS:

  • In 2022, Medicare enrollment was split equally between Medicare Advantage and traditional Medicare. Overall, more than 4 in 10 Medicare beneficiaries (44%), including beneficiaries in traditional Medicare and Medicare Advantage, had additional coverage from an employer or union sponsored plan (24%) or Medicaid (19%).

  • Nearly 90% of people in traditional Medicare had some form of additional coverage, such as Medigap (42%), employer or union-sponsored retiree health benefits (31%), or Medicaid (16%), but 11% (three million Medicare beneficiaries) had no additional coverage.

  • More than 40% of all Medicare Advantage enrollees also had some form of coverage from Medicaid (23%) or a union/employer sponsored retiree health plan (18%) in 2022.

  • Beneficiaries in traditional Medicare with Medigap and employer-sponsored insurance had higher incomes, were in relatively good health, had more years of education, and were less likely to be under age 65 with disabilities than all traditional Medicare beneficiaries.

  • As more beneficiaries have shifted to Medicare Advantage plans, the number of Medicare beneficiaries in traditional Medicare with no additional coverage has declined from 5.6 million in 2018 to 3.2 million in 2022. Traditional Medicare beneficiaries with no supplemental coverage were more likely to be under the age of 65 and have relatively lower incomes compared to traditional Medicare beneficiaries overall.

  • Medicare Advantage enrollees were more likely to be Black or Hispanic, self-report relatively poor health, have incomes below $20,000 per person, and have lower levels of education, compared to traditional Medicare beneficiaries in 2022.

  • Dual-eligible individuals accounted for a larger number and share of Medicare Advantage enrollees (7.0 million; 23%) than traditional Medicare beneficiaries (4.6 million; 16%) in 2022. Dual-eligible individuals in both traditional Medicare and Medicare Advantage were more likely to have lower incomes, self-report relatively poor health, identify as Black or Hispanic, and be under age 65 with disabilities than the overall Medicare population.” 


Nearly 7 in 10 Medicare Beneficiaries Did Not Compare Plans During Medicare’s Open Enrollment Period “Key Takeaways

  • Overall, nearly 7 in 10 (69%) Medicare beneficiaries did not compare their own source of Medicare coverage with other Medicare options offered in their area during the 2021 open enrollment period, while 31% did so. A larger share of beneficiaries in traditional Medicare than in Medicare Advantage did not compare their own source of coverage with other plans (73% vs 65%).

  • Among Medicare Advantage enrollees, more than 4 in 10 (43%) did not review their current plan’s coverage to check for potential changes in their plan’s premiums or other out-of-pocket costs, while the remainder (57%) did so. A similar share (44%) did not review their current plan for potential changes in the kinds of treatments, drugs, and services that would be covered in the following year.

  • Most enrollees in Medicare Advantage prescription drug plans (82%) and stand-alone prescription drug plan (PDPs) (69%) did not compare their plan’s drug coverage with drug coverage offered by other plans in their area.

  • Medicare’s official information resources are used by half or fewer of Medicare beneficiaries, with just a quarter (26%) reporting calling the toll-free number, 4 in 10 (42%) reporting visiting the Medicare website, and slightly more than half (54%) reporting reading some or parts of the Medicare & You handbook.”

Healthcare costs at a post-pandemic high, US employers prioritize affordability and wellbeing “WTW’s 2024 Best Practices in Healthcare Survey found that U.S. employers project their healthcare costs will increase by 7.7% in 2025, compared with 6.9% in 2024 and 6.5% in 2023. As a result of this uptick in costs, employers are reaching beyond traditional cost-shifting strategies to improve healthcare affordability and employee health. More than half of employers (52%) plan to implement programs that will reduce total costs, and just as many (51%) intend to adopt plan design and network strategies that steer to lower-cost, higher-quality providers and sites of care. Only 34% expect to shift costs to employees through premium contributions, and just 20% will promote account-based health plans or high-deductible health plans.” 

About pharma

FDA approves a novel drug for schizophrenia, a potential game changer “The U.S. Food and Drug Administration late Thursday approved a new kind of drug to treat schizophrenia, a breakthrough after 70 years of incremental innovation that appears to avoid side effects that cause many patients to stop taking their medication.
The new drug, Bristol Myers Squibb’s Cobenfy, targets a different area of the brain than traditional antipsychotic drugs to relieve symptoms like delusions without causing patients to gain weight, fall asleep and experience involuntary muscle jerking.”

 About the public’s health

Raising Taxes On These Products Could Generate $3.7 Trillion, Says New Report “‘Health Taxes: A Compelling Policy for the Crises of Today’ just released on September 24 described what could happen if such taxes were raised so that prices of these products would be increased by 50% around the world. Such higher prices could discourage the use of these products and thus prevent the noncommunicable diseases or NCDs that tobacco, alcohol and sugary beverages may cause. At the same time, doing so could end up generating an additional $3.7 trillion in revenue over the next five years. And having an extra several trillion dollars available could be kind of helpful.”

WHO director general: A breakthrough global agreement on combatting antimicrobial resistance “At the U.N. General Assembly in New York on Thursday, all countries approved a major new political declaration to radically scale up efforts to combat antimicrobial resistance (AMR) — a major threat to modern medicine.” 

The Uneven Surge in Diabetes in the United States “Takeaway

  • The overall prevalence of diabetes increased by 18.6% (P < .001) from 2012 to 2022, with the highest prevalence observed among non-Hispanic Black individuals (15.8%) and people aged ≥ 65 years (23.86%).

  • The likelihood of being diagnosed with diabetes was 1.15 times higher in men than in women, 5.16 times higher in adults aged 45-64 years than in those aged 18-24 years, and 3.64 times higher in those with obesity than in those with normal weight.

  • The risk for being diagnosed with diabetes was 1.60 times higher among Hispanic individuals, 1.67 times higher among non-Hispanic Asian individuals, and 2.10 times higher among non-Hispanic Black individuals than among non-Hispanic White individuals.

  • Individuals with a college education and higher income level were 24% and 41% less likely, respectively, to be diagnosed with diabetes.”

Today's News and Commentary

About Covid-19

Free covid tests by mail program revived by Biden administration Use this site to order your free Covid tests.

About health insurance/insurers

Insurers Expand Coverage Of Prescriptions Written By Pharmacists “Health insurance companies are beginning to pay for more prescriptions written by pharmacists as more states ease prescribing rules.
The expansion of reimbursement and health insurance coverage of prescriptions written by pharmacists comes following so-called “test to treat” legislation, which bestows prescribing status on pharmacists. Such state laws are sweeping the country as more lawmakers pass legislation that expands the role of pharmacists to prescribe certain medicines.”

About hospitals and healthcare systems

AGE-FRIENDLY HOSPITAL RATING “The Age-Friendly Hospital Rating is a new structural measure included in the CMS 2025 IPPS Final Rule. This measure is designed to assess hospitals' commitment to delivering high-quality care to patients 65 and older. The rating focuses on five key domains: patient goals, medication management, frailty screening, social vulnerability, and leadership commitment.”

Estimation of Tax Benefit of US Nonprofit Hospitals “Analyzing data from Medicare Cost Reports, a total of 2927 US nonprofit hospitals received a $37.4 billion total tax benefit in 2021. Tax benefit varies widely across states and is highly concentrated among a small number of hospitals. More than half of the total tax benefit was received at the state and local levels.”
This research invites the question: Are these hospitals providing community benefit commensurate with these tax breaks?

About the public’s health

EPA must address fluoridated water's risk to children's IQs, US judge rules “A federal judge in California has ordered the U.S. Environmental Protection Agency to strengthen regulations for fluoride in drinking water, saying the compound poses an unreasonable potential risk to children at levels that are currently typical nationwide.
U.S. District Judge Edward Chen in San Francisco on Tuesday sided with several advocacy groups, finding the current practice of adding fluoride to drinking water supplies to fight cavities presented unreasonable risks for children’s developing brains.”
Comment: USPHS recommends water concentration of fluoride of 0.7mg/L. Adverse effects on children begin at 1.5mg/L.

Almost 200 Chemicals Linked to Breast Cancer Are Found in Food Packaging “Key Takeaways

  • Food packaging materials contain nearly 200 chemicals linked to breast cancer

  • Researchers identified 143 suspected carcinogens in plastic packaging, and 89 in paper or cardboard

  • There’s strong evidence that humans are regularly exposed to at least 76 of these chemicals “