Today's News and Commentary

About Covid-19

 COVID-19 cases to jump 80% by Dec. 7, Mayo forecasts The headline is the story.

Analysis of Failure Rates for COVID-19 Entrance Screening at a US Academic Medical Center “We found limited benefit in maintaining hospital entrance screening for COVID-19 symptoms, exposures, or travel. Of the nearly 1 million persons screened, less than 0.1% had a failed screening.”
Read the Discussion section for caveats.

About health insurance/insurers

 Providers in Direct Contracting Model saved Medicare $70M in 2021, CMS reports “The Direct Contracting Model saved Medicare $70 million in 2021 as the Biden administration plans a major overhaul to the value-based care program next year.
Recently released data from the Centers for Medicare & Medicaid Services (CMS) found that 53 direct contracting entities generated savings for Medicare and 38 organizations earned $47 million in shared savings in 2021, the first year of the model. In response to the public health emergency, the start of the performance year was delayed to April 1, 2021, leading to nine months of experience reflected in these results.
All 53 direct contracting entities received quality scores of 100 percent in areas such as patient satisfaction and unplanned admissions for patients with chronic conditions, according to an emailed announcement from CMS.”

Surprise Medical Billing Disputes Pile Up as Lawsuit Unfolds “Litigation over the Biden administration’s process for resolving surprise medical billing disputes threatens to exacerbate a growing backlog in claims and leave doctors without paychecks, health-care lawyers said.
A federal district court in Texas is slated to decide the validity of the Department of Health and Human Services’ revised process for settling disagreements between health insurers and providers over payment rates. It will hear arguments Dec. 20 in a case brought by the Texas Medical Association over a final rule outlining the independent dispute resolution process.”

Most common treatments subject to prior authorization Genetic testing and Specialty drugs top the list.

About the public’s health

WHO renames monkeypox as ‘mpox’ “The World Health Organization announced Monday that “mpox” is now the preferred name for monkeypox.
’Both names will be used simultaneously for one year while “monkeypox” is phased out,’ the organization said.”

Cervical Cancer Incidence Among US Women, 2001-2019 “Between 2001 and 2019, cervical cancer incidence declined or remained stable among US women except for the 30- to 34-year-old age group, in whom incidence increased 2.5% per year after 2012. The observed increase in incidence among 30- to 34-year-old women could be real as a result of a true increase in cervical cancer incidence or due to increased early detection with a stable disease occurrence. If the increase is real, it could be a result of missed screening opportunities at earlier ages, as suggested by the increase in squamous cell carcinoma and localized disease. It may also stem from a decrease in screening at younger ages.”

About healthcare IT

Prevalence and Sources of Duplicate Information in the Electronic Medical Record “In this cross-sectional analysis of 104 456 653 routinely generated clinical notes, 16 523 851 210 words (50.1% of the total count of 32 991 489 889 words) were duplicated from prior documentation. Duplicate content was prevalent in notes written by physicians at all levels of training, nurses, and therapists and was evenly divided between intra-author and inter-author duplication.”

Amwell exploring $200M buyout of online therapy provider Talkspace: media report The headline is the story.

Google Health strikes deal with iCAD to commercialize mammography AI “Google Health struck a deal with medical technology company iCAD to integrate its artificial intelligence technology into the company's breast imaging solutions.
It marks the first licensing and commercialization agreement for Google Health's mammography AI models and will integrate the technology into real-world clinical practice, according to the company. ICAD's tech is used in health systems and imaging centers across the U.S. and globally.”

Athenahealth looks to go public again “EHR vendor Athenahealth is looking to go public just 10 months after it was bought by Bain Capital and another private equity firm for $17 billion, the Boston Globe reported Nov. 28…
The company has gotten out of the hospital business, instead focusing on software and services for medical practices, adding more than 2,000 of them this year, according to the Globe. The vendor also sold its headquarters for $526 million to Alexandria Real Estate Equities in 2019.”

Today's News and Commentary

About health insurance/insurers

 Audits — Hidden Until Now — Reveal Millions in Medicare Advantage Overcharges “Newly released federal audits reveal widespread overcharges and other errors in payments to Medicare Advantage health plans for seniors, with some plans overbilling the government more than $1,000 per patient a year on average.
Summaries of the 90 audits, which examined billings from 2011 through 2013 and are the most recent reviews completed, were obtained exclusively by KHN through a three-year Freedom of Information Act lawsuit…”

Boost in people seeking HealthCare.gov coverage, HHS says “Nearly 3.4 million people have signed up for coverage — an increase of 17% compared to the same time last year. The boost in enrollment comes as the number of uninsured Americans this year reached a historic low of 8%.”

Medicare Advantage Premiums Rise, Zero-Dollar Premium Plan Uptake Declines “Medicare Advantage premiums rose to $7 per month on average for 2023 open enrollment season, an eHealth survey uncovered.
For the past four years, Medicare Advantage plan premium costs have been stable or falling. In 2019, the cost was $10 and by 2022 it had dropped to $4 per month. But now that trend is reversing and seniors will face, on average, a $3 premium hike…
During the 2022 open enrollment season, zero-dollar premium plans were responsible for keeping premium costs low. Zero-dollar premium health plans continue to be a significant share of Medicare Advantage plans. In fact, the number of Medicare Advantage plans with zero-dollar premiums has swelled from 59 percent in 2022 to 66 percent in 2023…Even though the number of plans with zero-dollar premiums grew in the past year, the percentage of beneficiaries who selected zero-dollar premium plans fell after four consecutive years of growth.”

Accounting for the Growth of Observation Stays in the Assessment of Medicare’s Hospital Readmissions Reduction Program [HRRP] Findings  In this cohort study including 8 944 295 hospitalizations, fully accounting for observation stays as both index hospital discharges and readmissions more than halved the apparent decrease in 30-day readmissions (−1.48 vs −0.66 percentage points). In addition, an association of the program with lower readmission rates identified when only inpatient hospitalizations were considered was not found.
Meaning  The findings of this study suggest that much of the estimated reduction in readmissions associated with the implementation of the HRRP can be attributed to reclassification of inpatient admissions to observation stays.”

Georgia moves ahead with Medicaid work requirement plan “he state plans to implement a new Medicaid expansion plan – Georgia Pathways — that includes work requirements next July after several years of legal wrangling over the controversial proposal.  
‘I can confirm that we are moving forward with implementing the Pathways plan,’ said Andrew Isenhour, a spokesman for Republican Gov. Brian Kemp. 
The limited Medicaid expansion plan will require enrollees to work, study or volunteer for at least 80 hours per month.”

About hospitals and healthcare systems

 Nonprofit health systems' Q3 earnings: Baylor Scott & White, Sutter Health's operations stand tall among the pack “Motley earnings numbers from more than a dozen major nonprofit health systems show third-quarter operating incomes landing on both sides of zero, though issues such as labor shortages, limited volume recovery and worsening payer mix look to be a constant across much of the sector.” 

About pharma

 FDA approves most expensive drug on market “The FDA approved a hemophilia B drug with a list price of $3.5 million — which could save the healthcare system millions per patient according to drug maker CSL Behring.
Hemgenix is the first and only onetime gene therapy treatment for adults with hemophilia B who ‘currently use factor IX prophylaxis therapy, or have current or historical life-threatening hemorrhage, or have repeated, serious spontaneous bleeding episodes,’ according to a Nov. 22 CSL release.”

Teva, AbbVie's Allergan lock in $6.6B deal to settle thousands of US opioid lawsuits “Under an agreement floated in July, Teva is on the hook to pay $4.25 billion—a sum that will be paid out over 13 years and includes up to $1.2 billion worth of Teva’s generic version of the overdose reversal drug Narcan. Allergan, for its part, will provide up to $2.37 billion to help state and local efforts to fight opioid addiction and substance use disorder in the U.S.”

‘Skinny labels’ on biosimilar medicines saved Medicare $1.5 billion over a recent five-year period “Ahotly contested provision of a federal law designed to speed copycat drugs to market and foster competition saved Medicare $1.5 billion from 2015 to 2020 — or nearly 5% of the $30.2 billion spent by the health care program — on just five medicines during that period, according to a new analysis.”

About the public’s health

The International Code of Medical Ethics of the World Medical Association “The World Medical Association (WMA) has developed the International Code of Medical Ethics as a canon of ethical principles for the members of the medical profession worldwide. In concordance with the WMA Declaration of Geneva: The Physician’s Pledge and the WMA’s entire body of policies, it defines and elucidates the professional duties of physicians towards their patients, other physicians and health professionals, themselves, and society as a whole.”

 Changes in Home Births by Race and Hispanic Origin and State of Residence of Mother: United States, 2019–2020 and 2020–2021 “Following average annual increases of 2% from 1990 (0.67%) to 2019 (1.03%), the percentage of home births rose 22% from 2019 to 2020 (1.26%), and another 12% from 2020 to 2021 (1.41%). The 2021 level was the highest since at least 1990, demonstrating a higher rate of increase in home births during the first 2 years of the COVID-19 pandemic. From 2020 to 2021, levels increased by 10% to 21% for each of the race and Hispanic-origin groups.” 

About healthcare IT

 Google rolls out search features that aim to make it easier to sign up for Medicaid, Medicare “When many people are looking to enroll in health benefits, they turn to Google as a source of key information on eligibility, the application process and in-network providers.
In this spirit, the Google Search team has quietly rolled out multiple features for its search engine that aim to make it easier for users to access key information about obtaining Medicaid and Medicare benefits, as well as which doctors locally accept those types of coverage.”

About health technology

 FDA classifies Baxter's hospital bed system recall as most serious “The U.S. health regulator on Wednesday classified the recall of hospital bed systems by Baxter International Inc as the most serious type, on concerns it could lead to life-threatening injuries or death…
The device was found to interfere with other nearby critical devices such as infusion pumps, insulin pumps, blood glucose sensors and bladder scanners, among others.The Food and Drug Administration said the interference from WatchCare may lead to erroneous reading or malfunctions on other devices, causing inappropriate medical treatment for patients.”

About healthcare finance

 Baxter's blunder with Hillrom raises questions about its future “Baxter International flubbed its biggest acquisition ever, tanking its stock price while raising doubts about CEO José Almeida’s growth strategy and potentially making Baxter itself a takeover target.
The Deerfield-based medical products manufacturer last month disclosed a $3.1 billion impairment charge related to the $10.5 billion purchase last year of Hillrom, confirming Almeida overpaid significantly for the Chicago-based maker of hospital equipment.”

Today's News and Commentary

About health insurance/insurers

 CENTENE SIGNS DEFINITIVE AGREEMENT TO DIVEST MAGELLAN SPECIALTY HEALTH “ Centene Corporation announced today that it has signed a definitive agreement to sell Magellan Specialty Health to Evolent Health, Inc. (Evolent). Subject to customary purchase price adjustments, Centene expects to receive over $750 million in the aggregate from the transaction.
Centene acquired Magellan Specialty Health, also known as NIA, in January 2022 as part of its acquisition of Magellan Health, Inc. Magellan Specialty Health is a leading specialty benefit management organization that offers industry-leading utilization management solutions to health plans, including radiology management, musculoskeletal management, physical medicine management, and genetic testing solutions.”

Federally-facilitated Exchange Improper Payment Rate Less Than 1% in Initial Data Release “The Centers for Medicare & Medicaid Services (CMS) announced today that the first improper payment rate for the Federally-facilitated Exchange (FFE) program was less than 1% for Benefit Year 2020, thanks in large part to the agency’s implementation of effective automated processes for the program’s eligibility determinations and payments. This finding highlights CMS’ commitment to being responsible stewards of public funds, and to ensuring the sustainability of its programs for future generations.”

About hospitals and healthcare systems

$2.4B Gundersen, Bellin merger to close Nov. 30 “The "merger of equals" was announced June 1 with the goal of both systems offering more resources and services to improve patient care. The health systems will have a balanced leadership structure, with CEOs and board chairs in both regions to have equal representation in decision making for the combined entity.”

 Mayo reports $157M Q3 income, salaries and benefits increase 3.5% “Rochester, Minn.-based Mayo Clinic reported a strong third-quarter operating margin despite challenges from workforce shortages and inflation. …
Mayo reported net operating income of $157 million on $4.12 billion for the third quarter of 2022. The health system's operating margin at the quarter's end was 3.8 percent.
Operating expenses hit nearly $4 billion for the quarter as well, a 7.1 percent increase over the same period last year. Salaries and benefits were up 3.5 percent to $2.3.”

Catholic Health suffers credit rating downgrade “Buffalo, N.Y.-based Catholic Health had its credit rating downgraded and is in danger of defaulting on its covenants, Moody's said Nov. 17.
The nonprofit health system, which serves residents in Western New York state with four acute care hospitals and several other facilities, saw its rating on approximately $364 million of debt drop from ‘B1’to ‘Caa2.’ Staffing costs, ongoing impacts from the pandemic and a prolonged labor dispute have resulted in ‘material cash flow losses,’ which are unlikely to go away anytime soon, Moody's said.”

Ascension creates foundation to address health inequities “Ascension, a 143-hospital nonprofit system based in St. Louis, has created a national philanthropic organization that will develop, support and promote health equity initiatives.
The Ascension Foundation will initially focus on programs that address generational poverty and help create economic stability for people, according to a Nov. 17 news release. The organization will also work on creating a diverse future healthcare workforce.”

No Surprises Act Prevents More than 9 Million Surprise Bills Since January 2022 “More than 9 million claims from health care facilities and providers were subject to the protections of the law, which limit out-of-pocket costs for consumers. The number of those claims disputed by providers or facilities has far exceeded the federal government’s initial prediction.”

About pharma

FDA approves Provention Bio's Tzield as first drug to delay onset of type 1 diabetes “The FDA granted clearance to Provention Bio's Tzield (teplizumab-mzwv), making it the first approved drug that can delay the onset of type 1 diabetes. John Sharretts, director of the Division of Diabetes, Lipid Disorders, and Obesity in the FDA's Center for Drug Evaluation and Research, said Tzield's "potential to delay clinical diagnosis of type 1 diabetes may provide patients with months to years without the burdens of disease." 
The drug is designed to bind to CD3, a cell surface antigen present on T lymphocytes, and its mechanism is believed to involve partial agonistic signalling and deactivation of pancreatic beta cell autoreactive T lymphocytes. Specifically, Tzield, which is administered by intravenous infusion once daily for 14 consecutive days, is indicated to delay the onset of stage 3 type 1 diabetes in adults and paediatric patients 8 years and older who currently have stage 2 type 1 diabetes.”

About the public’s health

 Association of Residential Racial and Economic Segregation With Cancer Mortality in the US  “In this ecological study of 3110 US counties, age-adjusted mortality rates were statistically significantly higher for the most deprived counties for all cancers combined and for 12 of 13 selected cancer sites compared with the most privileged counties, with the largest magnitude occurring with lung and bronchus cancer.” 

Today's News and Commentary

Oregon will be the first state to make affordable health care a constitutional right “Oregon will be the first state in the nation to enshrine the right to affordable health care in its constitution.
Ballot Measure 111 narrowly passed, with nearly 50.7% of voters in favor and 49.3% of voters opposed. The measure’s long-term impact on Oregon health care is unclear because it doesn’t prescribe how the state should ensure that everyone has affordable health care.
Measure 111 amends the Oregon constitution by adding: ‘It is the obligation of the state to ensure that every resident of Oregon has access to cost-effective, clinically appropriate and affordable health care as a fundamental right.’
Comment: This measure is truly a landmark for Americans. Nowhere in our Constitution or federal laws is the right to healthcare guaranteed. [The exceptions are EMTALA’s requirement to treat and the rights of prisoners to health care services.] The implementation is going to be difficult and costly, but starts with the definitions of “cost-effective, clinically appropriate and affordable health care.”
Check this site to see how close the vote was and how the majority of counties voted “No.”

About health insurance/insurers

What Will UnitedHealth’s New Trove of Claims Data Mean for Consumers? A must-read article from ProPublica.

Extra Benefits Offered by Medicare Advantage Firms Vary Worth a quick read- especially the charts.

 Most Adults in Medicaid-Enrolled Families are Unaware of Medicaid Renewals Resuming in the Future 
”Key Findings

  • Most adults with family Medicaid enrollment were not aware of the return to regular Medicaid renewals when the PHE expires.

    • 62 percent of adults with family Medicaid enrollment reported hearing nothing at all about the forthcoming eligibility redeterminations, 16.2 percent reported hearing some, and 15.7 percent reported hearing only a little.

    • Only 5 percent of respondents reported hearing a lot about the return to regular Medicaid renewals.

  • The most common source of information for those who had heard about the resumption of renewals was media or social media (34.3%), followed by a state agency (30.6%), a health insurance company or plan (24.5%), a healthcare provider (17.8%), or somewhere else (6.5%).

  • Half of respondents (50.4%) who had heard from a state agency or health plan about the upcoming change received a notification about the need to renew coverage.

    • Just one in five (21.3%) were told how to get assistance with the renewal process.

    • Less than one-third (29%) were informed of the coverage options available to them if they become ineligible for Medicaid.”

About hospitals and healthcare systems

 Advocate Aurora posts $310M Q3 loss “1. Advocate Aurora reported a $310.8 million loss for the third quarter and reported a $911.6 million loss for the nine months ending Sept. 30. The results are in stark contrast to the $1.5 billion recorded for the nine months ending figure in 2021.
2. Total quarterly revenue reached $3.6 billion, up 3 percent year over year. The health system reported nearly $3 billion of the revenue came from patient services. In July, Fitch affirmed an AA rating and stable outlook for the system's long-term indebtedness, and since then S&P affirmed its AA rating and Moody's affirmed an Aa3 rating as well.”

CommonSpirit reports $227M quarterly loss: 6 details “The 138-hospital health system reported $23 million income for the three months ending Sept. 30, down from $34 million over the same period last year. However, CommonSpirit received $325 million as part of the California provider fee program under the CMS-approved state plan amendment; after normalizing for the program, CommonSpirit reported a $227 million loss for the quarter.”

About the public’s health

 Prevalence and global estimates of unsafe listening practices in adolescents and young adults: a systematic review and meta-analysis “Unsafe listening practices are highly prevalent worldwide and may place over 1 billion young people at risk of hearing loss. There is an urgent need to prioritise policy focused on safe listening. The World Health Organization provides comprehensive materials to aid in policy development and implementation.” 

Changes in Home Births by Race and Hispanic Origin and State of Residence of Mother: United States, 2019–2020 and 2020–2021 “Following average annual increases of 2% from 1990 (0.67%) to 2019 (1.03%), the percentage of home births rose 22% from 2019 to 2020 (1.26%), and another 12% from 2020 to 2021 (1.41%). The 2021 level was the highest since at least 1990, demonstrating a higher rate of increase in home births during the first 2 years of the COVID-19 pandemic. From 2020 to 2021, levels increased by 10% to 21% for each of the race and Hispanic-origin groups. For all women and non-Hispanic White women, increases occurred generally for most months of the year, although not all increases were significant. Although less pronounced and consistent, increases also were seen in home births for most months for non-Hispanic Black and Hispanic women. Between 2020 and 2021, home births increased in 41 states (changes in 11 states were not significant) and declined in 9 states and D.C. (changes in 7 states and D.C. were not significant).”

Lung cancer screening rates in US ‘simply unacceptable’ “An estimated 14.2 million Americans meet the U.S. Preventive Services Task Force recommendation for lung cancer screening. The task force recommends annual screening with low-dose CT scan for individuals aged 50 to 80 years who have a 20 pack-year smoking history and either currently smoke or quit within the past 15 years.
Only 5.8% of Americans who meet those criteria have undergone lung cancer screening, according to the report. Analyses by state show rates are lowest in California (1%) and Nevada (1.3%) and highest in Massachusetts (16.3%)…
White individuals appeared more likely to be diagnosed at an early stage (27%) than Black (23%), Latino (23%), Asian/Pacific Islander (22%) and American Indian/Alaska Native (23%) individuals.”

Chest CT Findings in Marijuana Smokers “Airway inflammation and emphysema were more common in marijuana smokers than in nonsmokers and tobacco-only smokers, although variable interobserver agreement and concomitant cigarette smoking among the marijuana-smoking cohort limits our ability to draw strong conclusions.”

FDA Warns Firms for Selling Illegal E-cigarettes That Look Like Toys, Food, and Cartoon Characters “Today, the U.S. Food and Drug Administration issued warning letters to five firms for the unauthorized marketing of 15 different e-cigarette products. Each e-cigarette product is packaged to look like toys, food, or cartoon characters and is likely to promote use by youth. None of the manufacturers submitted a premarket application for any of the unauthorized products.”

Mode of delivery modulates the intestinal microbiota and impacts the response to vaccination “Here we assess the association between mode of delivery, gut microbiota development in the first year of life, and mucosal antigen-specific antibody responses against pneumococcal vaccination in 101 infants at age 12 months and against meningococcal vaccination in 66 infants at age 18 months. Birth by vaginal delivery is associated with higher antibody responses against both vaccines. Relative abundances of vaginal birth-associated Bifidobacterium and Escherichia coli in the first weeks of life are positively associated with anti-pneumococcal antibody responses, and relative abundance of E. coli in the same period is also positively associated with anti-meningococcal antibody responses.”

About healthcare IT

 Mental Health Apps Are Not Keeping Your Data Safe “We surveyed 132 studies that tested automation technologies, such as chatbots, in online mental health initiatives. The researchers in 85 percent of the studies didn’t address, either in study design, or in reporting results, how the technologies could be used in negative ways. This was despite some of the technologies raising serious risks of harm. For example, 53 studies used public social media data—in many cases without consent—for predictive purposes like trying to determine a person’s mental health diagnosis. None of the studies we examined grappled with the potential discrimination people might experience if these data were made public.” 

About healthcare personnel

 Healthcare employment in 20 numbers FYI

Today's News and Commentary

Global population hits 8 billion as growth poses more challenges for the planet

About Covid-19

Cost of COVID-19 hospital admissions among people with private health coverage “We find that, in 2020, COVID-19 hospitalizations cost an average of $41,611, including an average out-of-pocket payment of $1,280 for people with large employer coverage. In 2020, many private insurers and employers temporarily waived out-of-pocket costs for COVID-19 treatment (this is generally no longer the case). For COVID-19 hospitalizations with some cost-sharing expense, an average of $1,880 was spent out-of-pocket by individuals with large employer coverage.”

Biden requests $9.25 bln for COVID, $37.7 bln for Ukraine from Congress -officials “The Biden administration is asking Congress for $9.25 billion to fight COVID-19…
The administration is also requesting $750 million to fight other infectious diseases and will be seeking additional money for natural disaster relief, the officials said.”

NICE recommends 3 treatments for COVID-19 in draft guidanceThree treatments for COVID have been recommended in draft NICE guidance released today for public consultation.
The recommended treatments are:

  • Nirmatrelvir plus ritonavir (also called Paxlovid and made by Pfizer).

  • Tocilizumab (also called RoActemra and made by Roche).

  • Baricitinib (also called Olumiant and made by Eli Lilly and company, subject to it receiving a marketing authorisation in Great Britain for treating COVID-19).”

Post–COVID-19 Symptoms 2 Years After SARS-CoV-2 Infection Among Hospitalized vs Nonhospitalized Patient Findings  This cross-sectional study found that the proportion of patients with at least 1 post–COVID-19 symptom 2 years after acute infection was 59.7% for hospitalized patients and 67.5% for those not requiring hospitalization. No significant differences in post–COVID-19 symptoms were seen between hospitalized and nonhospitalized patients.
Meaning  Similar rates of post–COVID-19 symptoms between hospitalized and nonhospitalized patients suggest that, among all patients who contract COVID-19, these sequelae deserve attention.”

About health insurance/insurers

 Working full time doesn’t always make it easier to get health insurance at the job “Though the number of full-time, year-round workers ages 19 to 64 jumped by 10.4 million last year, the uninsured rate of this group also rose – by 0.6 percentage points to 9.1%, according to Census Bureau data.
That’s partly because the occupations that had the largest increases in the share of full-time, year-round workers last year were service and construction, which are less likely to provide job-based health benefits. Only about 62% of service workers and 56% of construction workers have employer-sponsored insurance.
At the same time, the share of employees in professional and management occupations – which have the highest rates of workplace coverage at 89% and 85%, respectively – declined somewhat last year. This also contributed to the drop in coverage among all full-time, year-round workers.”

About hospitals and healthcare systems

Midwest nonprofits Sanford Health, Fairview Health Services target a 58-hospital merger for 2023 “The nonprofits have signed a nonbinding letter of intent as they proceed with due diligence and regulatory antitrust reviews, they said in a press release. Each would maintain their own regional presence, leadership and regional boards but operate as a single integrated system under Sanford Health’s banner.
The organizations said they anticipate closing their deal sometime next year.”

CommonSpirit Health kicks off its fiscal 2023 with a $397M net loss, 0.3% operating margin “The system’s $23 million operating income (0.3% margin) for the three months ended Sept. 30 represents a slight decline from the $34 million (0.4%) recorded during the same time last year.
Operating revenue for the quarter rose to about $9.01 billion from the previous year’s $8.55 billion (5.4% year-over-over increase).”

 Leapfrog Group Releases New Hospital Safety Grades, Marking 10th Anniversary “Highlights from the fall 2022 Leapfrog Hospital Safety Grade include:

  • Thirty percent of hospitals received an "A," 28% received a "B," 36% received a "C," 6% received a "D," and 1% received an "F.”

  • The top ten states with the highest percentages of "A" hospitals are New Hampshire, Virginia, Utah, Colorado, Idaho, New Jersey, North Carolia, Maine, Pennsylvania, and Florida.

  • There were no “A” hospitals in the District of Columbia, North Dakota, or Vermont.” 

About pharma

 Optum to add biosimilars to formulary to tackle the massive cost of Humira “Optum Rx, the pharmacy benefit management subsidiary of UnitedHealth Group, manages more than 66 million members and is one of the three largest PBMs that dominate the market, alongside CVS Health's Caremark and Cigna's Express Scripts.
The company said it will place those biosimilars on its formulary at parity with Humira, meaning they'll be on the same tier. The first biosimilar to compete with Humira will arrive next year and will be the first added to the formulary. 
The goal, CEO Heather Cianfrocco said at a HLTH session Tuesday, is to make a dent in rising specialty drug costs, which represent just 2% of prescriptions but 50% of costs. Optum Rx said Humira alone accounts for $20 billion in sales each year.”

AbbVie Reaches $54.4 Million Settlement Over Its Alzheimer’s Drug “AbbVie has agreed to a $54.4 million settlement for alleged anticompetitive abuse of the generic pharmaceutical approval process involving Namenda (memantine hydrochloride), an FDA-approved drug to treat Alzheimer’s.”

Deductibles and Coinsurance Drive High Out-Of-Pocket Costs For Commercially Insured Patients Taking Brand Medicines “As new data shows, this discriminatory practice can lead to higher costs for patients at the pharmacy. For commercially insured patients taking one or more brand medicines in 2021, the sponsored health care data analytics firm IQVIA found that:

  • Patients with deductibles or coinsurance spent six times ($261) more out of pocket, on average, for their brand and generic medicines than patients with only copays.

  • Insurers and PBMs subjected two-thirds of patients to the medicine’s full list price through the use of deductibles or coinsurance.

  • Deductibles and coinsurance accounted for 60% of patients’ out-of-pocket spending on brand medicines.

  • Patients filling a brand prescription in the deductible paid eight times more for their medicine than patients filling a brand prescription with copays.

  • Patients were nearly four times more likely to abandon newly prescribed brand medicines filled in the deductible compared to those filled with copays.

  • Patients using cost-sharing assistance to access their brand medicines reduced their annual out-of-pocket costs by nearly 60%, leading to average savings of nearly $500.”

About the public’s health

 Screening for Obstructive Sleep Apnea in Adults “The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for OSA in the general adult population. (I statement)”

FDA moves to boost access to overdose reversal med with preliminary over-the-counter endorsement “In a Federal Register notice issued Tuesday, the U.S. drug regulator released its preliminary assessment that certain naloxone products “may be approvable”—i.e., safe and effective—for over-the-counter use. The decision—while not a formal OTC approval determination—is many years in the making and could ease development and approval of nonprescription naloxone, the agency said in a release. This could include transforming the approvals for existing prescription naloxone products into OTC nods.”

Notable Survey: 61% of Patients Skip Medical Appointments Due to Scheduling Hassles The headline is the story.

Judge overturns Georgia’s six-week abortion ban “A Fulton County judge has overturned Georgia’s six-week abortion ban, ruling that two key parts of the law “were plainly unconstitutional when drafted, voted upon, and enacted” and writing that the law cannot be enforced.
The 15-page ruling by Fulton County Superior Court Judge Robert McBurney stemmed from a lawsuit that argued the state’s “heartbeat bill” violated pregnant people’s liberty and privacy rights under Georgia’s constitution. The plaintiffs also argued that the law violatedthe U.S. Constitution at the time it was enacted — in 2019, when Roe v. Wade was still the law of the land.”

About healthcare IT

 Best Buy expands push into home healthcare with investment in remote patient monitoring firm “Best Buy has made an initial investment in remote patient monitoring company Coeus h3c as the tech retailer looks to expand in the home healthcare market.
Coeus h3c offers a cloud-based platform that automates technology and logistics processes for remote patient monitoring vendors.”

Mayo Clinic launches digital referee for spotting potential bias in healthcare AI programs “Dubbed Platform_Validate, the program is designed to put an algorithm’s credibility to the test, and act as a third party to confirm the AI’s efficacy in meeting its intended clinical purpose. 
By generating standard reports on specificity and sensitivity, the Mayo Clinic said it aims to address some of the skepticism of implementing AI programs in healthcare and diagnostics—especially where programs may inadvertently reinforce inequities in the current system, by underlining disparities present in potentially poor-quality data used to construct and train the algorithm in the first place.”

Teladoc Health Reaches 50 Million Visit Milestone The headline is the story.

About healthcare finance

 DispatchHealth raises $330M led by Optum Ventures “Home healthcare company DispatchHealth has raised $330 million in a funding round led by Optum Ventures, Home Health Care News reported Nov. 15.
DispatchHealth offers on-demand in-home acute care delivered by emergency and internal medicine teams. Blue Shield of California was among the other investors.

Today's News and Commentary

About health insurance/insurers

Trends in Social Spending by Private Health Insurers “Between 2017 and 2021, total identifiable social spending for the top 20 private health insurers was at least $1.87 billion. The top 6 insurers by market share made up 72% of total social spending. As a percent of net income, these six insurers, on average, spent 0.11% of dollars on SDoH in 2017, 1.6% in 2020, and 0.67% in 2021. Most funds went to housing ($1.2 billion) and food security ($238 million) programs. $247 million were allocated towards “general SDoH.” The least amount of funding was directed to transportation ($13.4 million), followed by social and community context ($49.7 million), education ($57.2 million), and employment ($58.6 million).”

About hospitals and healthcare systems

 Illinois OKs Atrium, Advocate Aurora merger “The Illinois Health Facilities and Services Review Board unanimously approved a plan to change ownership for 10 Advocate Aurora facilities in the state covered by the system's plan to merge with Charlotte, N.C.-based Atrium Health…”

AHA: Drugmaker 340B restrictions are harming safety net hospitals financially “A new hospital industry report charges that safety net and charity care hospitals are losing millions due to drug companies cutting off sales of pharmaceuticals discounted under the 340B program to contract pharmacies.
The report, released Monday and conducted by the American Hospital Association (AHA), focuses on the impact of restrictions conducted by nearly 20 drugmakers. The federal government and some of the companies have been battling in court over the moves.”

Cleveland Clinic to bill up to $50 for MyChart messages “Cleveland Clinic will begin to bill for Epic MyChart messages requiring a provider's clinical time and expertise beginning Nov. 17.
Patients have been able to send MyChart messages for free, and providers typically respond within three business days. But now the health system plans to bill for messages about medication changes, new symptoms, changes to long-term medical conditions, checkups on long-term conditions and requests to complete medical forms sent through MyChart, according to a news release from Cleveland Clinic.
Messages to schedule an appointment, get prescription refills and ask questions that could lead to an appointment will remain free. Patients can also give providers health updates without any extra charges.”
Other systems are also starting to implement these types of charges.

Oracle Cerner, Labcorp partner to manage hospital labs in 10 states “Oracle Cerner has partnered with life sciences company Labcorp to manage hospital-based laboratories in 10 states. 
Under the partnership, Cerner's laboratory information system will help Labcorp centralize operations and streamline processes within the hospital-based labs at a leading health system, according to a Nov. 14 press release from Oracle Cerner. The aim is to enhance patient care and improve lab efficiency. 
The partnership also allows Labcorp to build and expand upon the labs' existing technologies to standardize and optimize workflows for better efficiency as well as support information sharing across the health system.”

Providence's operating loss grows to $1.1B for 2022 “Providence, a 51-hospital system headquartered in Renton, Wash., ended the first nine months of 2022 with an operating loss of $1.1 billion, according to financial documents released Nov. 14. 
The system said in a Nov. 11 news release that its third quarter financial results showed the ‘ongoing impact of inflation, the national healthcare labor shortage, delayed reimbursement from payers, global supply chain disruptions and financial market weakness.’”

Hospital acquired infections were on the rise in 2021, says CDC “Several healthcare acquired infections (HAIs), such as central line-associated bloodstream infections and ventilator events, showed increased prevalence in 2021, according to new data released by the Centers for Disease Control and Prevention.
Four of six common infections increased over 2020, with the biggest increase occurring with Methicillin-resistant Staphylococcus aureus (MRSA), which showed a 14% year-over-year increase. 
Following that were ventilator-associated events (VAEs) at 12%; central line-associated bloodstream infections (CLABSIs) at 7%; and catheter-associated urinary tract infections (CAUTIS) at 5%.”

About pharma

 Walmart Agrees to Pay $3.1 Billion to Settle Opioid Lawsuits “Walmart, the largest retailer in the United States, has agreed to pay $3.1 billion to resolve thousands of lawsuits over its pharmacies’ roles in the opioid crisis, the company and lawyers for states, local governments and tribes announced Tuesday.” 

About the public’s health

More than 100 healthcare organizations have signed on to climate resilience pledge, HHS says “More than 100 health systems, payers, drug manufacturers, associations and other industry organizations have signed on to the Biden administration’s greenhouse gas and climate resilience pledge, according to a Department of Health and Human Services (HHS) announcement timed with the United Nations Climate Change Conference (COP27).

Inappropriate outpatient antibiotics linked to adverse drug events, excess health care costs “Of nearly 3.3 million eligible adults (median age, 43 years; 41% male), 43% and 56% received inappropriate antibiotics for sinusitis and pharyngitis, respectively. For viral infections, 7%, 32%, 52%, and 66% received inappropriate antibiotics for influenza, viral upper respiratory infection, nonsuppurative otitis media, and bronchitis, respectively.”

The FDA has banned certain vapes and medicines. We still bought these 13 products in its backyard From a STAT investigation: “The Food and Drug Administration, as the name suggests, is supposed to police the United States’ food and drug supply.
But there are still illegal products available for easy purchase at gas stations and convenience stores all over the country — including in the FDA’s own backyard. We know, we bought them.
Some of the products STAT found around the FDA’s suburban Maryland campus are outright dangerous, like an unapproved cough medicine linked to childrens’ deaths. Others, like CBD gummies and vapes, have become ubiquitous at convenience stores, but are still illegal nonetheless.”

About healthcare IT

 Consolidated telemedicine implementation guide From the WHO: In response to the global increase in demand, this guide provides an overview of key steps and considerations for implementing telemedicine and optimizing its benefits and impact. The guide aims to be an evolving document that harnesses learnings emerging from the COVID-19 pandemic, while synthesizing key considerations from WHO resources relevant developed over the past decade. Overall, this consolidated guide provides a comprehensive overview of the key planning, implementation and maintenance processes to inform a costed investment plan and support countries across different stages in their telemedicine journey.” 

Amazon Clinic makes debut “Amazon is expanding its healthcare presence with a new virtual offering called Amazon Clinic.
Amazon Clinic, unveiled on Nov. 15, will allow patients in 32 states to message clinicians through a secure portal to seek personalized treatments and prescriptions for common conditions such as urinary tract infections, dandruff and migraines. Patients can also seek birth control options, according to a press release from Amazon.”

About healthcare personnel

Primary Care Physician Supply by County-Level Characteristics, 2010-2019 “The number of PCPs per 100 000 population did not meaningfully increase across US counties by poverty quartile or racial and ethnic minority concentration between 2010 and 2019. However, counties with the second-highest poverty level experienced a decline in PCP supply, potentially due to federal policies preferentially allocating resources to counties with the highest poverty level. The number of PCPs per capita also declined in counties in rural areas and in the South. As a result, the rural-urban difference in PCP supply widened over the study period.
Despite recent federal investments, PCP supply has remained unchanged or even worsened among communities that face unmet health needs.”

 Average Appointment Wait Times Across 15 Metro Markets “The average appointment wait time, measured across five specialties in 15 metropolitan areas, is 26 days in 2022. This represents an increase of 8% over 2017 – the last time wait times were measured in the same survey…

Of the five different specialties included in the survey, average wait time was as follows:

  • dermatology: 34.5 days

  • OB-GYN: 31.4 days

  • cardiology: 26.6 days

  • family medicine: 20.6 days

  • orthopedic surgery: 16.9 days”

Today's News and Commentary

About Covid-19

U.S. COVID public health emergency to stay in place “The public health emergency was initially declared in January 2020, when the coronavirus pandemic began, and has been renewed each quarter since for 90 days. But the government in August began signaling it planned to let it expire in January.
The U.S. Department of Health and Human Services (HHS) has promised to give states 60 days' notice before letting the emergency expire, which would have been on Friday if it did not plan on renewing it again in January. The agency did not provide such notice…”

Moderna says new booster increases protection against omicron subvariants “In blood drawn from people who received the bivalent booster, omicron-blocking antibody levels shot up 15 times higher than their pre-booster levels, Moderna said in a news release. The findings, which are not yet peer-reviewed, are similar to results Pfizer and its German partner, BioNTech, presented this month about their bivalent coronavirus vaccine booster.”

Lifting Universal Masking in Schools — Covid-19 Incidence among Students and Staff “Among school districts in the greater Boston area, the lifting of masking requirements was associated with an additional 44.9 Covid-19 cases per 1000 students and staff during the 15 weeks after the statewide masking policy was rescinded.”

Repeat COVID is riskier than first infection, study finds “Reinfected patients had a more than doubled risk of death and a more than tripled risk of hospitalization compared with those who were infected with COVID just once. They also had elevated risks for problems with lungs, heart, blood, kidneys, diabetes, mental health, bones and muscles, and neurological disorders, according to a report published in Nature Medicine.”

 Some Employers Still Require COVID-19 Vaccines “Employer vaccination requirements decreased this year from 34 percent in 2021 to 32 percent, Mercer found in a survey of more than 700 employers. Fewer employers required one booster (16 percent) or two (11 percent).
If a spike in COVID-19 infections occurs this winter, 52 percent of surveyed businesses said they are providing additional paid time off for employees recovering from COVID-19.”

About health insurance/insurers

 U.S. judge rejects Biden administration's LGBT health protections “A federal judge in Texas ruled on Friday that President Joe Biden's administration had wrongly interpreted an Obamacare provision as barring health care providers from discriminating against gay and transgender people.
U.S. District Judge Matthew Kacsmaryk in Amarillo ruled that a landmark U.S. Supreme Court decision in 2020 holding that a law barring workplace discrimination protects gay and transgender employees did not apply to the healthcare law.”

About hospitals and healthcare systems

Hospital double whammy: Less cash in, more cash out “A nationwide healthcare worker shortage has increased the need for hospitals to rely on contract labor, resulting in a 37% increase per patient in labor costs for hospitals between 2019 and March 2022…
According to Crowe research, in the summer of 2021, hospitals on average had collected 97% of their expected cash within six months. During the same period in 2022, that percentage dropped to 94%. The three-percentage-point decrease in cash coupled with a more than 9% increase in expenses creates a minimum of a 12% negative impact on a health system’s finances…
Prior-authorization denials on inpatient accounts are a key driver behind the dollar value of denials increasing to 2.5% of gross revenue in August 2022 from 1.5% of gross revenue in January 2021. That’s an increase of 67%.”
And in a related article: Health system cash reserves plummet

 Best Hospitals and Surgery Centers for Billing Ethics “…Money and The Leapfrog Group’s Best Hospitals and Surgery Centers for Billing Ethics… selected the facilities that are most likely to play fair with your bill.”

About pharma

 Eli Lilly lost billions after fake Twitter account promotes free insulin “On Nov. 10, a verified Twitter account posed as Eli Lilly wrote in a viral tweet, "We are excited to announce insulin is free now." By the next day, the drugmaker's shares plunged by about $22 billion. 
The fake account, which has since been taken down, had a verified blue check and a copy of the Indianapolis-based company's logo as its profile picture. Eli Lilly responded within two hours, but the tweet that stayed on the app for less than a day accumulated thousands of retweets.”  

About the public’s health

 Tobacco Product Use Among Middle and High School Students — United States, 2022  “In 2022, nearly one in nine (11.3%) middle and high school students reported current tobacco product use, including 13.5% of non-Hispanic American Indian or Alaska Native students; 16.0% who identified as lesbian, gay, or bisexual; 16.6% who identified as transgender; 18.3% who reported severe psychological distress; 12.5% with low family affluence; and 27.2% with low academic achievement.”

Trends in inequalities in the prevalence of dementia in the United States “The age-adjusted prevalence of dementia decreased from 12.2% in 2000 (95% CI, 11.7 to 12.7%) to 8.5% in 2016 (7.9 to 9.1%) in the 65+ population, a statistically significant decline of 3.7 percentage points or 30.1%. Females are more likely to live with dementia, but the sex difference has narrowed. In the male subsample, we found a reduction in inequalities across education, earnings, and racial and ethnic groups; among females, those inequalities also declined, but less strongly. We observed a substantial increase in the level of education between 2000 and 2016 in the sample. This compositional change can explain, in a statistical sense, about 40% of the reduction in dementia prevalence among men and 20% among women, whereas compositional changes in the older population by age, race and ethnicity, and cardiovascular risk factors mattered less.”

About healthcare personnel

 Association of State Share of Nonphysician Practitioners With Diagnostic Imaging Ordering Among Emergency Department Visits for Medicare Beneficiaries Question  Are emergency department (ED) nonphysician practitioner (NPP) encounters associated with more imaging studies than physician encounters?
Findings  In this cross-sectional study of 16 922 274 ED visits by Medicare fee-for-service beneficiaries in 2005-2020, the presence of NPPs in the ED compared with no NPPs was associated with 5.3% more imaging studies per ED visit.”

About health technology

 Referencing the Definition of "Device" in the Federal Food, Drug, and Cosmetic Act in Guidance, Regulatory Documents, Communications, and Other Public Documents The FDA is redefining “Device” and introducing the “Counterfeit device”. Prior to this action, the latter could fit the device definition and technically be “legal.”

About healthcare finance

 Opiant, maker of Narcan, to be acquired in $145 million deal “Shares of Opiant Pharmaceuticals Inc. OPNT, 111.89% soared 120.8% in premarket trading on Monday after the company, which is best known for selling the opioid overdose treatment Narcan, said it will be acquired by Indivior PLC INDV, +2.36% for $145 million. The deal also includes additional potential milestone payments tied to revenue for a still investigational opioid overdose treatment.”

Ionis, Metagenomi pen Big Pharma-sized genetic target pact that could total almost $3B “Ionis Pharmaceuticals and budding gene editing company Metagenomi have penned a multi-target research collaboration that could total almost $3 billion in biobucks. 
The gargantuan financial deal is astounding for two companies that are not heralded as large pharmas, but nonetheless, the announcement shows just how much the industry is betting on gene editing. The agreement is essentially split into two groups of four possible genetic targets—Ionis is paying $80 million for the first batch of four, with two of the targets being co-developed with Metagenomi.”

Lantheus promises up to $2B for 2 of the biotech's cancer radiopharmaceutical therapies “Lantheus is paying $260 million upfront for a double bill of licenses for two of POINT Biopharma’s radiopharmaceutical oncology candidates, with another $1.8 billion tied up in biobucks.
Under the agreements, POINT will continue to fund and complete its phase 3 SPLASH trial for PNT2002, a prostate-specific membrane antigen (PSMA)-targeting 177Lu-based radiopharmaceutical therapy for metastatic castration-resistant prostate cancer. After that, Lantheus will work with POINT to file the therapy for FDA approval.
The other candidate is PNT2003, a somatostatin receptor-targeted radioligand in development for gastroenteropancreatic neuroendocrine tumors.”

Today's News and Commentary

About Covid-19

WHO reports 90% drop in world COVID-19 deaths since February “Director-General Tedros Adhanom Ghebreyesus said that last week just over 9,400 deaths linked to the coronavirus were reported to the WHO. In February of this year, he said, weekly deaths had topped 75,000 globally.” 

About health insurance/insurers

 Americans must work 504 hours to cover typical hospital stay “Workers making the average American salary of $26.22 an hour need to work 504 hours to cover the cost of a typical 4.6-day hospital stay, according to an Oct. 17 report from the personal finance site ValuePenguin.”

Elevance Health to acquire specialty pharmacy BioPlus “The insurer, formerly Anthem, has entered into an agreement with CarepathRx to pick up BioPlus, which offers a range of specialty pharmacy options for patients with chronic conditions such as cancer, multiple sclerosis, autoimmune conditions and hepatitis C. BioPlus will enable Elevance Health to better meet the specialty drug needs of its patients in a whole-person manner, in collaboration with other services across the health plan and its Carelon portfolio.
BioPlus will be folded into Elevance's pharmacy benefit management arm, IngenioRx.”

About pharma

 Walgreens Faces $10B Opioid Trial Threat Despite $5B Deal New Mexico and Walgreens have submitted written closing arguments in the Land of Enchantment's opioid trial, and the state said it wants nearly $10 billion in damages — twice as much as Walgreens offered last week to settle opioid litigation across the entire country…”  

About healthcare IT

 Hospitals Should Be Wary of Using Meta Pixel & Other Third-Party Analytics Tools “ECRI recently issued an alert warning hospitals about the cybersecurity risks associated with the use of third-party analytics tools, such as Meta Pixel, Google Analytics and Adobe Analytics. When providers install these tools on their websites and patient portals, they may be exposing patient data — which tech companies can use to target medical-related ads to consumers as they browse the Internet.”

The lawsuit that could rewrite the rules of AI copyright “Microsoft, its subsidiary GitHub, and its business partner OpenAI have been targeted in a proposed class action lawsuit alleging that the companies’ creation of AI-powered coding assistant GitHub Copilot relies on “software piracy on an unprecedented scale.” The case is only in its earliest stages but could have a huge effect on the broader world of AI, where companies are making fortunes training software on copyright-protected data.
Copilot, which was unveiled by Microsoft-owned GitHub in June 2021, is trained on public repositories of code scraped from the web, many of which are published with licenses that require anyone reusing the code to credit its creators. Copilot has been found to regurgitate long sections of licensed code without providing credit — prompting this lawsuit that accuses the companies of violating copyright law on a massive scale.”

Amazon’s leaked ‘Clinic’ would connect patients to telemedicine “Amazon might have a new healthcare offering coming soon, according to a leaked video. A video published to the company's YouTube page Tuesday — and then quickly taken down — described ‘Amazon Clinic,’ an online care program that would offer treatment for ‘common conditions’ like allergies and acne.
As described in the video, people could fill out a questionnaire about their symptoms and pay a fee. A clinician would review their answers and provide a diagnosis and prescriptions as needed. ‘Telehealth services are offered by third-party healthcare provider groups,’ according to the text in the video.”

About healthcare personnel

 Physician Flash Report “ Key Takeaways

  1. Expenses for providers (including physicians) are outpacing revenues.

    While revenue for physicians and other providers increased in Q3 2022, expenses rose at a faster rate.

  2. Investment/subsidies grew in Q3.

    The gap between expenses and revenues translated to higher rates of investment/subsidy in physicians and other providers by health systems.

  3. Volumes for providers (including physicians) were up in Q3.

    Volumes and a corresponding increase in provider productivity could not close the gap on growing expenses. Going forward, simply increasing volume may not be the solution to the negative operating margins that it was in previous years.

  4. Health systems must assess how service lines affect margins.

    Health systems must evaluate and think carefully about where to grow volume, focusing on balancing service lines that positively affect their margins with their mission. 

Today's News and Commentary

Election overview: Some specific outcomes are explained below. As of this writing, the Republicans have narrowly captured the House. The Senate, however could end up in a 50-50 split, depending on the Georgia runoff in December.
The implications for healthcare are, as usual, uncertain. The House Republicans may not do much of anything beyond trying to impeach the President and hold hearings about the (post-Trump) handling of Covid.
Even if both houses flip “red”, the President still has a veto that cannot be overridden, as well as the power of executive orders.
For now…wait and see.

About Covid-19

 COVID-19 cases to jump 39% by Nov. 17, Mayo forecasts “COVID-19 cases are projected to increase by nearly 40 percent over the next two weeks, though it's still unclear whether hospitalizations and deaths may follow suit in November, according to national disease modeling.”

Comparative Risk of Myocarditis/Pericarditis Following Second Doses of BNT162b2 and mRNA-1273 Coronavirus Vaccines Myocarditis/pericarditis following mRNA COVID-19 vaccines is rare, but we observed a 2- to 3-fold higher odds among individuals who received mRNA-1273 [Moderna] vs BNT162b2 [Pfizer/BioNTech]. The rate of myocarditis following mRNA-1273 receipt is highest among younger men (age 18-39 years) and does not seem to be present at older ages. Our findings may have policy implications regarding the choice of vaccine offered.”

About health insurance/insurers

Person-Centered Innovation – An Update on the Implementation of the CMS Innovation Center’s Strategy
”In October 2021, the Center for Medicare and Medicaid Innovation (Innovation Center) launched a renewed vision focused on five objectives to support and help execute CMS’ vision and priorities . This report provides an update on the Innovation Center's progress in the implementation of the new strategy, describes areas of focus for the coming year, and begins the process of measuring progress against the five objectives.”
The five objectives are:
DRIVE ACCOUNTABLE CARE
ADVANCE HEALTH EQUITY
SUPPORT INNOVATION
ADDRESS AFFORDABILITY
PARTNER TO ACHIEVE SYSTEM TRANSFORMATION”
For the media’s take on this document, see: Medicare eyes changes to pay for specialty care

 Cigna: Tracking 'vitality' is the key to measuring whole-person health “Cigna's Evernorth has launched a new index aimed at tracking patients' vitality, which the company is touting as the ‘next-generation measure of health.’
Evernorth said it's calculating vitality using eight elements of health: physical, spiritual, emotional, environmental, social, occupational, financial and intellectual. The index also accounts for how people feel about their own ability to manage their life across those factors, or their autonomy, relatedness and competence, Cigna said.”
The highest score is for those over 65 and the lowest is for those 18-24.

South Dakota votes to expand Medicaid “South Dakota voters on Tuesday approved a measure to expand the state’s Medicaid program under the Affordable Care Act.
The program, which takes effect in July and is expected to cover more than 40,000 people, passed with about 56 percent support.”

Oscar Health largely abandons Medicare Advantage “Oscar Health has largely abandoned its Medicare Advantage business, opting to focus on ACA exchange plans, CEO Mario Schlosser told investors on a Nov. 9 call. 
Mr. Schlosser said the company has exited MA markets in New York and Texas. The company's lone remaining plan is a partnership with Holy Cross Health and Memorial Healthcare system in Broward County, Fla.”
Do check the financials. Revenues and membership are up, loss ratio is down; however expenses are up.
If companies can’t make money on Medicare advantage, something is wrong with management.

Assessment of Immigrants’ Premium and Tax Payments for Health Care and the Costs of Their Care Question  Do insurers and US government programs pay more for the care of immigrants than immigrants contribute to the health care system in insurance premiums and taxes?
Findings  In this cross-sectional analysis of 210 669 respondents to the Medical Expenditure Panel Survey and the Current Population Survey, immigrants contributed $58.3 billion more in premiums and taxes in 2017 than insurers and government paid for their health care, and US-born citizens incurred a net deficit of $67.2 billion. Undocumented immigrants accounted for most (89.0%) of the surplus.”
From an accompanying editorial: The broad strokes of this analysis are (1) immigrants generally use fewer health care services than similar US-born citizens and therefore have lower medical expenditures, and (2) immigrants typically pay taxes and health insurance premiums like most citizens, but (3) federal policies make it more difficult for many immigrants, particularly undocumented immigrants, to receive governmental health assistance from programs such as Medicaid, Medicare, and the Affordable Care Act health insurance marketplaces.”
Another myth about immigration debunked.

About hospitals and healthcare systems

 Mass General Brigham turning away offensive, violent patients under new 'Patient Code of Conduct' “Mass General Brigham (MGB) unveiled the new policy last week in an email notice to existing patients and an update to its online resources for patients and visitors. Physical copies of the policy will also be posted in MGB hospitals…
The notices outlined five specific examples of patient, family, visitor or research participant behaviors that will no longer be tolerated at its care locations:

  • Offensive comments about others’ race, accent, religion, gender, sexual orientation or other personal traits

  • Refusal to see a clinician or other staff member based on these personal traits

  • Physical or verbal threats and assaults

  • Sexual or vulgar words or actions

  • Disrupting another patient’s care or experience

MGB said patients believed to have violated the code will have a chance to plead their case before we make any decisions about future care at [MGB].’”

About pharma

 Statins may prevent people from losing eyesight in later life “Experts, led by a team from University Hospital Bonn in Germany, examined 14 studies involving almost 40,000 people from the UK, France, Germany, Greece, Ireland, Italy, Norway, Portugal and Russia.
They found that people taking statins were 15% less likely to go on to develop age-related macular degeneration (AMD).”

Mindfulness-Based Stress Reduction vs Escitalopram for the Treatment of Adults With Anxiety Disorders: A Randomized Clinical TrialQuestion  Is mindfulness-based stress reduction noninferior to escitalopram for the treatment of anxiety disorders?
Findings  In this randomized clinical trial of 276 adults with anxiety disorders, 8-week treatment with mindfulness-based stress reduction was noninferior to escitalopram.”

Amazon Pharmacy is scooping up payer contracts A good summary about how this Amazon business is expanding.

About the public’s health

 California bans flavored tobacco products, including vapes “The move makes California by far the largest state to ban such products, which are already illegal in a smattering of smaller states, including Rhode Island, New Jersey, and Massachusetts.
Regulators have targeted flavored products in particular because they are overwhelmingly preferred by young people. More than 84% of young people who vape reported using flavored products, according to recently released survey data by the Centers for Disease Control and Prevention.”

Michigan, Vermont, and California affirm abortion rights, as Kentucky voters shoot down anti-abortion amendment “Voters in Kentucky shot down a proposal that would have explicitly denied abortion as a right in its constitution, though the procedure still remains all but banned in the state. In a closely watched fight in Michigan, voters passed a measure that would protect abortion access in the state constitution. Voters in California and Vermont also voted to codify abortion as a constitutional right, while in Montana, voters weighed in on a measure requiring care for fetus born alive after an abortion attempt. That measure was largely expected to pass but remains in close contention with 80% of votes counted.”

About healthcare IT

 Hims & Hers bucks health tech's downward trend, boosts 2022 revenue guidance “The telehealth company, which sells prescription and over-the-counter drugs online as well as personal care products, reported better-than-expected revenue growth in the latest quarter, reporting its top line grew 95% to reach $144.8 million mostly due to its online business segment. The company's top line beat Wall Street estimates as analysts expected revenue of $130.3 million in the third quarter.
This was the company's third consecutive quarter posting more than $100 million in revenue.
Hims & Hers also netted 70,000 new subscribers during the quarter, bringing the total subscriber count to 991,000, up 80% year over year.”

About healthcare finance

 Healthcare Dealmakers—UHG wraps up Change Healthcare deal; Rural systems eye 25-hospital merger and more A good review of activities in several health sectors.

Walgreens cuts AmerisourceBergen stake by $2 billion “The sale priced early Tuesday at $155.20 per share, a 4.2% discount from Monday’s closing trade, according to a person familiar with the matter, who asked not to be named. AmerisourceBergen shares hit an intraday high on Friday, jumping the most in nearly two years on an outlook that surpassed Wall Street estimates.”

Today's News and Commentary

About health insurance/insurers

 UnitedHealth continues to lead the way on insurer profits in Q3. Here's how its competitors fared “In the third quarter, UHG reported $5.3 billion in profit. It's next-closest competitor, Cigna, posted $2.8 billion in profit. UnitedHealth is also comfortably out in front on profit through the first three quarters of the year, with the healthcare giant reporting $15.35 billion in profit through the first nine months of 2022.
Cigna also reported the second-highest profit through the first nine months of this year, posting $5.5 billion.
UnitedHealth Group edges out CVS Health for the highest revenue through the first three quarters of 2022, reporting $241.4 billion. CVS Health posted $238.6 billion in revenue through Sept. 30 of this year.”

About pharma

Patent wars: Moderna’s battle for the spoils of Covid vaccines “In autumn 2020, as drugmakers raced to get vaccines to market in the face of the biggest public health crisis in a generation, Moderna made a bold pledge: it would not enforce its patents against rivals developing Covid-19 jabs. This year, however, almost two years after Pfizer and BioNTech beat it to the first approved mRNA jab, Moderna fired back with a lawsuit over patents for a technology that could open the door to many more vaccines. If Moderna wins, it could gain a slice of billions of dollars in revenues from the BioNTech/Pfizer Covid jab. Perhaps more importantly, it would also signal to investors and Big Pharma that the Massachusetts-based company is primed to dominate the future mRNA market.”

 Gilead dodges Supreme Court review—and a $1.2B fine—in CAR-T patent feud with Bristol Myers “After years of courtroom drama and amid a market clash, Bristol Myers Squibb has failed to open a new legal front in its cell therapy war with Gilead Sciences.
Monday, the U.S. Supreme Court declined to hear BMS’ case to resurrect a $1.2 billion win in the five-year dispute over a BMS CAR-T patent and Gilead’s cell therapy Yescarta.”

 Troubled Lupin suspends manufacturing of drugs bound for US “Indian generics manufacturer Lupin has suspended production of drugs bound for the U.S. from a troubled active pharmaceutical ingredient plant in India, according to an FDA warning letter.”

About the public’s health

 Physician Attitudes About Using Life Expectancy to Inform Cancer Screening Cessation in Older Adults—Results From a National Survey ”This study found that approximately a quarter of physicians did not consider life expectancy a reasonable criterion for stopping cancer screening in older adults. Together with a study showing that older adults do not perceive life expectancy as relevant in cancer screening,4 our findings question whether reframing guidelines away from the life expectancy label may be more acceptable to physicians and patients. For example, life expectancy and age-specific cancer mortality have been combined to estimate the risk of dying from that cancer in one’s remaining lifetime.1 Although this calculation fundamentally relies on life expectancy, framing screening cessation as when cancer mortality risk is too low to justify the harms involved may be more acceptable.”

Don’t bother with dietary supplements for heart health, study says “Some people believe that common dietary supplements – fish oil, garlic, cinnamon, turmeric, plant sterols and red yeast rice – will lower their ‘bad’ cholesterol. ‘Bad’ cholesterol, known in the medical community as low-density lipoproteins or LDL, can cause the buildup of fatty deposits in the arteries. The fatty deposits can block the flow of oxygen and blood that the heart needs to work and the blockage can lead to a heart attack or stroke…
None of the people who took the supplements saw any significant decrease in LDL cholesterol, total cholesterol or blood triglycerides, and their results were similar to those of people who took a placebo. While there were similar adverse events in all the groups, there were a numerically higher number of problems among those who took the plant sterols or red yeast rice.”

Express Scripts to shell out $3.2M in prescription drug pricing case “Express Scripts agreed to settle for $3.2 million in a Massachusetts case that accused the pharmacy benefit manager of overcharging for some injured workers' prescriptions. 
Attorney General Maura Healey said Express Scripts allegedly "billed and obtained payment for prescription drugs from payers of workers' compensation claims in excess of amounts" permitted by state law at CVS, Walgreens and Rite Aid locations, according to a court document filed Nov. 7.”

About healthcare IT

 Telehealth Utilization in Nation as a Whole Remained Relatively Stable “Telehealth utilization in the nation as a whole, as measured by telehealth’s share of all medical claim lines, remained relatively stable in August 2022, as it had in July. Nationally, telehealth utilization increased 1.9 percent, from 5.3 percent of medical claim lines in July to 5.4 percent in August. In the Midwest and Northeast there was no change in telehealth utilization. In the South, telehealth utilization increased 4.7 percent and, in the West, it decreased 1.4 percent.” 

About healthcare personnel

 Oak Street reports $130M net loss even as revenues rise significantly “Oak Street Health, which operates a network of over 160 primary care clinics for Medicare patients across 21 states, reported a net loss of $130.4 million for the third quarter ending Sept. 30. The net loss for the first nine months of the year was $375.3 million.
Those numbers come as the company reported revenues rising to total $545 million for the third quarter and almost $1.6 billion for the nine month period. Those figures compare with revenues of $388.7 million and $1.04 billion in the respective periods in 2021.”

About health technology

 First ever clinical trial of laboratory grown red blood cells being transfused into another person “Red blood cells that have been grown in a laboratory have now been transfused into another person in a world first clinical trial.
The manufactured blood cells were grown from stem cells from donors. The red cells were then transfused into volunteers in the RESTORE randomised controlled clinical trial.
This is the first time in the world that red blood cells that have been grown in a laboratory have been given to another person as part of a trial into blood transfusion.”

Air power: UConn researchers charge neurostim implants by collecting electricity from breaths “Somewhat similar to a pacemaker, a deep brain stimulator delivers pulses to the brain multiple times per second to regulate its electrical activity. The implants can help patients with Parkinson’s disease better control their motor muscles or potentially reduce the symptoms of severe depression.
But while a pacemaker’s batteries can last as long as a decade under certain conditions, brain stimulators use much more power and typically require surgery to swap them out every two to three years.
But according to the UConn researchers, their implant never needs its batteries changed. It relies on a small device that uses the expansion and contraction of the chest each time the user takes a breath to generate and store small amounts of electricity.”

About healthcare finance

 Oracle Sells $7 Billion of Debt to Help Fund Cerner Purchase “Oracle also increased its previous term loan by $1.3 billion
Acquisition was funded with $15.7 billion of bridge loan debt

Today's News and Commentary

Walgreens' VillageMD completes $8.9B deal to combine with Summit Health “Primary care disruptor VillageMD, which is majority owned by Walgreens Boots Alliance, has aquired physician practice group Summit Health in a transaction worth roughly $8.9 billion. 
The deal combines Village Practice Management with Summit Health, the parent company of CityMD urgent-care centers, according to a Nov. 7 press release from Walgreens Boost Alliance. 
Walgeens Boost Alliance has invested $3.5 billion, through a mix of debt and equity, to support the acquisition, making it the largest and consolidating shareholder of VillageMD with approximately 53 percent ownership. 
Payer Cigna has also invested in the combined company and will serve as a minority owner in VillageMD.”

About Covid-19

 COVID variants BQ.1/BQ.1.1 make up 35% of U.S. cases “The U.S. Centers for Disease Control and Prevention (CDC) on Friday estimated that Omicron subvariants BQ.1 and BQ.1.1 accounted for about 35% of coronavirus cases in the country in the week ending Nov.5 compared with 23.2% in the previous week.
The subvariants made up nearly 9% of total cases in the week of Oct. 15 and their proportion has been rising steadily among circulating cases since then.”

About health insurance/insurers

 Kaiser Permanente reports $1.5B Q3 loss “Oakland, Calif.-based Kaiser Foundation Health Plan, Kaiser Foundation Hospitals and their subsidiaries reported a net loss of $1.5 billion for the quarter ending Sept. 30, according to a Nov. 4 financial report.
The company posted total operating revenues of $24.3 billion and total operating expenses of $24.3 billion for the quarter. Total operating revenues of $23.2 billion and total operating expenses of $23.1 billion for the same period in 2021. 
Additionally, there was an operating loss of $75 million in the third quarter compared to an operating income of $38 million in the third quarter of 2021, according to a Nov. 4 news release.”

About hospitals and healthcare systems

OCTOBER 2022 National Hospital Flash Report Key Takeaways:

  1. Margins remain negative in September.

    Hospital operating margins in September were negative, and are still negative for the year to date, reversing modest gains from previous months. Year to date, the hospital operating margin stands at -0.1%.

  2. Revenue decreases drive negative margins.

    A drop in revenues across the board, with declines in discharges, inpatient minutes, and operating minutes, kept hospital margins in the red in September.

  3. Sicker patients affect discharges and lengths of stay.

    Sicker patients and labor shortages in post-acute settings drove the decline in discharges and an increase in the average length of stay fueled by more observation days.

  4. Expenses slow but not enough.

    Hospital expenses decreased slightly in September but could not keep pace with the drop in revenue and volume. Year to date, when adjusted for volume, expenses have actually increased; they have improved year over year and month over month, however.

  5. Margin performance may force hospitals into difficult decisions.

    When taken altogether, the expense pressures and volume and revenue declines could force hospitals to make difficult decisions around the services they are able to safely provide to patients.”

 78% of hospitals say their relationships with payers are getting worse “Hospitals are growing increasingly frustrated with payers, a survey from the American Hospital Association found….
Of the hospitals surveyed, 84 percent said the cost of complying with insurer policies is increasing, and 95 percent reported increases in staff time spent seeking prior authorization approval.”

Sutter Health blunts its difficult 2022 with a $103M Q3 profit “The Sacramento, California-based nonprofit health system reported a $103 million net gain for the three-month period ended Sept. 30, thanks in large part to $288 million in operating income.
This whittled its year-to-date losses down to $538 million, as opposed to the $641 million six-month net loss of June.”

About the public’s health

 Routine Vaccination Coverage — Worldwide, 2021 “In 2021, the estimated global coverage with 3 doses of diphtheria-tetanus-pertussis–containing vaccine as well as the first dose of measles-containing vaccine decreased to 81%, the lowest level since 2008. Globally, 25.0 million children were unvaccinated or incompletely vaccinated in 2021, 5.9 million more than in 2019.”

About healthcare personnel

 Association Between Nephrologist Ownership of Dialysis Facilities and Clinical Outcomes “Findings  In this cross-sectional cohort study of 251 651 adults receiving dialysis, nephrologist ownership of dialysis facilities was associated with increased home dialysis use and decreased erythropoietin-stimulating agent use but not adverse outcomes associated with lower doses, such as more severe anemia or increased blood transfusions.
Meaning  This study found that nephrologist ownership was not associated with worse clinical outcomes, suggesting that such ownership may be associated with improved care quality in some domains: home dialysis and erythropoietin-stimulating agent use.”
See the accompanying editorial:  Physicians as Owners and Agents—A Call for Further Study

Today's News and Commentary

About Covid-19

 Pfizer says new booster shot increases omicron-fighting antibodies “Pfizer announced Friday that its updated coronavirus booster shot targeting the omicron variant succeeded in strengthening the body’s army of disease-fighting antibodies, even as questions persist about the vaccine’s continued effectiveness against a swarm of later-generation versions of omicron.” 

About health insurance/insurers

 Consolidated Appropriations Act shifts more power, responsibility to employers next year “The Consolidated Appropriations Act that passed this year will next year make self-insured employers the fiduciaries for the healthcare services that they purchase, which means they’ll have more say about quality and cost but also more responsibility.
This portion of the approximately 5,600-page act hasn’t gotten as much attention as, for instance, the parts that guard against surprise billing of patients or expand patient access to telehealth, but it could mean a significant shift in power toward employers, experts say.
‘That is a role that they are prepared to take on effectively, but that means all the partners that they rely on—their PBMs, pharma, health plans, consultants—will have to become transparent and accountable,’ Elizabeth Mitchell, CEO of the Purchaser Business Group on Health…”

Private Medicare Plans Misled Customers Into Signing Up, Senate Report Says “Companies selling private Medicare plans to older adults have posed as the Internal Revenue Service and other government agencies, misled customers about the size of their networks and preyed on vulnerable people with dementia and cognitive impairment, according to a new investigation of deceptive marketing practices in the industry released Thursday by Democrats on the Senate Finance Committee.
Many individuals say they were enrolled in plans without realizing it.
The report catalogs complaints from 14 states, and a multitude of marketing materials generated by the insurers and the companies they hire to help sell the private plans.”

New study shows Medicare Advantage markets lack competition “The 2022 edition of Competition in Health Insurance: A Comprehensive Study of U.S. Markets for the first time examines Medicare Advantage markets in 380 metropolitan statistical areas (MSAs) and presents the two largest insurers' market shares and market concentration levels as measures of competition. Nearly 4 out of 5 (79%) MSAs had Medicare Advantage markets with low levels of competition as these local-level markets ranked “highly concentrated” according to federal guidelines.”

About hospitals and healthcare systems

 631 rural hospitals at risk of closure by state “Across the U.S., a total of 631 rural hospitals — or about 30 percent of all rural hospitals — are at risk of closing in the immediate or near future due to persistent financial losses on patient services, inadequate revenues to cover expenses, and low financial reserves, according to a report from the Center for Healthcare Quality and Payment Reform.
More than 200 of the rural hospitals in the report are identified as being at immediate risk of closure.”

Half of All Hospitals Have Charity Care Costs That Represent 1.4% or Less of Their Operating Expenses “Half of hospitals reported that the cost of providing charity care to patients represented 1.4% or less of their operating expenses in 2020, though the rates vary widely from hospital to hospital, a new KFF analysis finds.
Based on a review of hospital cost report data, the analysis finds some hospitals provide little or no charity care (0.1% or less of operating expenses at 8% of hospitals), while others provide far more charity care (at least 7% of operating expenses at 9% of hospitals).”

About the public’s health

 CDC Clinical Practice Guideline for Prescribing Opioids for Pain — United States, 2022 This guideline provides recommendations for clinicians providing pain care, including those prescribing opioids, for outpatients aged ≥18 years.” The CDC last revised these criteria in 2016.

AstraZeneca, Sanofi bag first approval for RSV preventative Beyfortus with EU nod “AstraZeneca and Sanofi announced Friday that Beyfortus (nirsevimab) gained approval in the EU for the prevention of respiratory syncytial virus (RSV) lower respiratory tract disease in newborns and infants during their first RSV season. The companies noted that clearance by the European Commission is the first regulatory authorisation for the single-dose, long-acting antibody.”

About healthcare IT

 Telehealth physical therapy associated with decreased utilization, patient satisfaction “Researchers found telehealth PT utilization decreased from 1,676 visits in 2020 to 340 visits in 2021, while in-person PT utilization increased from 22,586 visits in 2020 to 37,055 visits in 2021.
After review of the 1,012 completed patient surveys, Kim and colleagues found 75% of telehealth patients and 89.1% of in-person patients were likely to recommend their encounter to others, while 71.7% of telehealth patients and 88.6% of in-person patients rated their overall visit as the top-box score. Researchers also noted telehealth users were more often female, English-speaking, in the lowest quartile for median household income, had Medicare insurance carriers, were living out-of-county or living in nonurban areas.”

Today's News and Commentary

About health insurance/insurers

 Cigna posts $2.8B in profit on Q3 earnings beat “The insurer reported $2.8 billion in profit for the quarter, up from $1.6 billion in the third quarter of 2021. In addition, Cigna posted revenues of $45.3 billion, up slightly from $44.3 billion in the prior-year quarter, according to its earnings report released Thursday.”

Most and Least Expensive States for Health Care, Ranked See the interactive figures.
“Key Takeaways

  • South Dakota topped the list of states with the most expensive health care, while Michigan is the cheapest.

  • Forbes Advisor’s analysis found that the eastern part of the country is where you may find the most expensive health care costs. Five of the 10 most expensive states for medical care are in the east, including West Virginia, Florida, Maine, Delaware and New Hampshire.

  • The western part of the country has many of the cheapest states for health care, including Washington, Nevada, Hawaii, New Mexico and Oregon.”

About pharma

 New U.S. cancer drug prices rise 53% in five years -report “The annual price of a newly-launched cancer drug in the United States averaged $283,000 last year, a 53% increase from 2017, according to a new report from U.S. Democratic Representative Katie Porter, a consumer bankruptcy law professor running for re-election in California.”
The article has many product examples. 

NY Reaches $523M Opioid Deal With Teva The headline is the story.

Moderna slashes billions from its sales forecast after a quarter of 'pain points' “On Thursday, the company said it deferred between $2 billion and $3 billion in vaccine sales to 2023. As a result, Moderna has slashed its annual sales projection for Spikevax from $21 billion to a range of $18 to $19 billion.
Third quarter sales of the shot, at $3.12 billion, came in below Wall Street’s expectations. The figure represented a 35% decrease from the third quarter of last year and 31% decline from the second quarter of this year.”

CMS sets court-ordered 340B drug payments, but leaves back payment issues unresolved “The American Hospital Association and 340B Health applauded CMS' final ruling for its 2023 Medicare outpatient prospective payment system (OPPS) that will restore payments for drugs to 340B hospitals to the same amounts all other hospitals receive, but were disappointed that past repayment issues have still not been resolved.  
From 2018 to 2022, many 340B hospitals were paid nearly 30 percent less for drugs administered to Medicare patients, according to 340B Health. The Supreme Court ruled in June that those cuts were unlawful.”

About the public’s health

 HHS renews public health emergency for monkeypox outbreak “The Department of Health and Human Services (HHS) on Wednesday renewed the national public health emergency for the monkeypox outbreak, with officials stating that the virus is still very present in the U.S. even as cases continue to drop…
The public health emergency for monkeypox was first signed on August 4. Public health emergencies from HHS end after 90 days unless they are renewed.”

Enhancing pharmacists' prescribing power boosts access to PrEP: GoodRx study “The research, provided exclusively to Fierce Healthcare, found that fills for PrEP increased by 24% in one year in states that passed pharmacist prescriber policies for these drugs. Fills grew 110% after two years, the study found.
By comparison, PrEP fills remained largely flat in states that did not expand phamacists' prescribing power, the study gound. The findings suggest pharmacists could play a key role in helping people who live in underserved or underresourced areas access critical preventive drugs like PrEP.”

Sleep doctors’ orders: Use standard time 365 days a year “In a position statement published in the Journal of Clinical Sleep Medicine, the American Academy of Sleep Medicine (AASM) is unequivocal in advocating elimination of daylight saving time, the practice of setting clocks ahead one hour between mid-March and early November.
‘The U.S. should eliminate seasonal time changes in favor of a national, fixed, year-round time,’ says the position statement, adding that ‘current evidence best supports the adoption of year-round standard time, which aligns best with human circadian biology and provides distinct benefits for public health and safety.’”

CDC wants to change ‘antiquated’ rules that hamper agency’s ability to fight Covid, polio and other diseases “ Despite having a multibillion-dollar budget, the agency doesn’t have authority from Congress to hire consultants in a timely way when an urgent situation arises.”

About healthcare IT

What Consumers Want from Virtual Primary Care – Findings A good review of patient wants and attitudes

 HHS Seeks to Prevent Discrimination by Clinical Algorithms “The US Department of Health and Human Services (HHS) intends to add language to a federal rule to make it clear that physicians could be held accountable for decisions made while relying on clinical algorithms that discriminate on the basis of a patient's race.
The intent, HHS said, is to make physician practices and hospitals take a closer look at clinical decision support algorithms. Overreliance on algorithms could lead to violations of Section 1557 of the Affordable Care Act, which prohibits discrimination on the basis of sex, gender, race, and other identities.”

Biometrics Can Help Match Patients to Their Electronic Health Records From a Pew Foundation study:

“The work group participants reached consensus on the following positions:

  • Facial imaging is an optimal type of biometrics because it is relatively inexpensive and contactless, and people are already used to having their picture taken for identification purposes. However, the technology raises issues related to privacy, equity, and data security.

  • Storing encrypted biometrics on patients’ personal devices (such as smartphones) is preferable to storing them in a single national repository or across various health systems’ databases. Called “match-on-device,” this approach reduces security and privacy risks but can introduce logistical and accessibility-related challenges, especially for patients without a smartphone or broadband internet connection.

  • Biometrics should be used alongside demographic data such as address, birthdate, and Social Security number to match patient records; they should not be the sole matching mechanism. (As a result, this report uses the term “biometrics-enhanced patient matching” to describe this hybrid approach.)

  • National policies and standards are needed to ensure that different health care and EHR systems can exchange information as easily as possible. Further, biometrics technology should not favor or be based on any particular vendor’s proprietary technology, which could limit usability.

  • Patients’ rights should be at the center of decisions around biometric standards. Federal legislators and regulators should study the extent to which existing privacy regulations apply to biometrics and enact and enforce additional policies as needed to protect patients’ biometrics from being misused for data mining, surveillance, or other purposes for which patients do not provide informed consent.”

About healthcare finance

 20 largest healthcare companies by revenue FYI

Thermo Fisher wagers on early cancer diagnostics in $2.6B cash deal for multiple myeloma test maker “The life sciences conglomerate is shelling out $2.6 billion (£2.25 billion) to acquire The Binding Site Group from a group of private equity investors, integrating a suite of diagnostic assays and instruments for blood cancers and immune system disorders into its specialty diagnostics business.
In particular, Thermo Fisher highlighted The Binding Site’s tests for multiple myeloma diagnosis and monitoring as a standout product.”

Today's News and Commentary

About health insurance/insurers

CMS releases final payment rules for 2023: 15 takeaways A good summary of the rules for 2023.

 Hospitals, Surgery Centers Get Payment Bump Under Medicare Plan  “Providers caring for Medicare beneficiaries in hospital outpatient departments will receive a 3.8% payment increase in 2023, or roughly $6.5 billion more than in 2022, the Biden administration reported Tuesday.
Medicare payments to ambulatory surgical centers will also increase 3.8% next year, up $230 million compared with 2022, according to the new final payment rule (RIN 0938-AU82).
The pay hikes will push total Medicare payments to an estimated $86.5 billion for hospital outpatient care next year, while payments to ambulatory surgical centers will reach an estimated $5.3 billion.”

 Humana's $1.2B Q3 “Humana reported $1.2 billion in profits during the third quarter and is expecting major increases in Medicare Advantage membership, according to the company's Nov. 2 earnings report.
The company reported $22.8 billion in third quarter revenues, increasing 10.2 percent from $20.7 billion year over year. Total revenues in 2022 are $70.4 billion “

About hospitals and healthcare systems

 Medicare Fines for High Hospital Readmissions Drop, but Nearly 2,300 Facilities Are Still Penalized “The average payment reduction was 0.43%, also the lowest since 2014. The reductions will be applied to each Medicare payment to the affected hospitals from Oct. 1 through next September and cost them $320 million over that 12-month period.”

About pharma

 CVS, Walgreens announce opioid settlements totaling $10B “The two largest U.S. pharmacy chains, CVS Health and Walgreen Co., announced agreements in principle Wednesday to pay about $5 billion each to settle lawsuits nationwide over the toll of opioids, and a lawyer said Walmart, a third pharmacy behemoth, is in discussions for a deal…
The deals, if completed, would end thousands of lawsuits in which governments claimed pharmacies filled prescriptions they should have flagged as inappropriate. With settlements already proposed or finalized between some of the biggest drugmakers and distribution companies, the recent developments could be the among the last multibillion-dollar settlements to be announced.
They also would bring the total value of all settlements to more than $50 billion, with most of it required to be used by state and local governments to combat opioids, which have been linked to more than 500,000 deaths in the U.S. over the last two decades.”

Estimating Savings Opportunities From Therapeutic Substitutions of High-Cost Generic Medications “This cross-sectional study of the top 1000 CO-APCD generics identified 45 high-cost products that had lower-cost therapeutic alternatives of same clinical value. Overall, high-cost generics were 15.6 times more expensive than their therapeutic alternatives (median values). If the lower-cost alternatives had been used, total spending would have been reduced from $7.5 million to $873 711, resulting in 88.3% savings. Most substitutions (28 of 45 [62.2]%) involved different dosage forms or different strengths of the same drug and provided mean (SD) discounts of 94.9% (3.8%) and 77.1% (19.9%), respectively.”

About the public’s health

 Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Persons “The USPSTF recommends against the use of combined estrogen and progestin for the primary prevention of chronic conditions in postmenopausal persons. (D recommendation) The USPSTF recommends against the use of estrogen alone for the primary prevention of chronic conditions in postmenopausal persons who have had a hysterectomy. (D recommendation).” 

Estimated Deaths Attributable to Excessive Alcohol Use Among US Adults Aged 20 to 64 Years, 2015 to 2019 “The estimates in this cross-sectional study of 694 660 mean deaths per year between 2015 and 2019 suggest that excessive alcohol consumption accounted for 12.9% of total deaths among adults aged 20 to 64 years and 20.3% of deaths among adults aged 20 to 49 years. Among adults aged 20 to 64 years, the proportion of alcohol-attributable deaths to total deaths varied by state.”

About healthcare personnel

 Addressing the healthcare staffing shortage “As of Q4 2021, a total of 230,609 healthcare providers have left the profession.” The report details the numbers by specialty and type of practitioner. 

About health technology

 Johnson & Johnson doles out $16.6B to snatch up miniaturized heart pump maker Abiomed “The deal includes an upfront cash payment of $380 per share, representing a 50% premium over Abiomed’s closing stock price the day before the announcement. Shareholders will also be able to receive another $35 per share if Abiomed’s pipeline and portfolio pass certain clinical and commercial milestones.”

BioIntelliSense launches skin tone-sensitive pulse oximetry sensor as FDA meets on racial biasAccording to BioIntelliSense, the system continuously adjusts the amount of light emitted based on its absorption by the skin to ensure the blood cells are being illuminated at equal levels; darker skin tones have been found to absorb more light before it can reach the tissue.
The company reported that several studies of its pulse oximetry chipset have confirmed that it can detect hypoxia—in which blood oxygen drops to potentially life-threateningly low quantities—with similar accuracy across all skin tones, even when tested on a variety of oxygen saturation levels.”

Abbott blood test that spots concussions in 15 minutes makes ER debut “After more than a decade of research, the Abbott Laboratories test is being used for the first time in a real-world setting to evaluate patients at Tampa General Hospital in Florida. Doctors using the test say it’s better at evaluating concussions than the brain scans that have been widely used for the last 30 years.”

Today's News and Commentary

About health insurance/insurers

 Home Health Agencies Get $125M Payment Boost from Medicare “Home health agencies will receive a 0.7 percent Medicare payment boost under the calendar year (CY) 2023 Home Health Prospective Payment System (HH PPS) Rate Update final rule, translating to an extra $125 million next year.
The final rule released yesterday says that the Medicare payment increase reflects a 4.0 percent home health payment update percentage, which will add $725 million, and a 0.2 percent increase because of an update to the fixed-dollar loss ratio (FDL) used in determining outlier payments, which will add $35 million.”

 CMS Finalizes Medicare Reimbursement Increase for ESRD Facilities “CMS has finalized a 3.1 percent increase in Medicare reimbursement for end-stage renal disease (ESRD) facilities in the Calendar Year (CY) 2023 ESRD Prospective Payment System (PPS) final rule.
Medicare will pay a projected $7.9 billion in 2023 to the 7,800 ESRD facilities that furnish renal dialysis services to beneficiaries. The CY 2023 ESRD PPS base rate is $265.57, representing a $7.67 increase from the current base rate of $257.90.”

About hospitals and healthcare systems

 Price Transparency Impact Report  See page 14 for a summary of compliance rates.

About pharma

 Walgreens-Backed VillageMD Said to Explore Deal for Summit  “VillageMD, which is majority owned by Walgreens Boots Alliance Inc., is exploring a deal to merge with Warburg Pincus-backed Summit Health, according to people familiar with the matter. 
The acquisition by primary-care provider VillageMD of Summit, a health-care network and the parent of CityMD, would value the combined entity at between $5 billion to $10 billion, said the people, who asked to not be identified because the matter isn’t public.”

About the public’s health

 A new tool to prevent malaria shows promise: Antibody drugs “A single dose of an antibody drug provided strong protection against malaria infections during the six-month rainy season in Mali, an international team of researchers announced Monday. The promising result, published in the New England Journal of Medicine, lays the groundwork for a new tool to help defeat a parasitic disease that last year killed more than 600,000 people — mostly children.” 

Association of Maternal Caffeine Consumption During Pregnancy With Child Growth “In this cohort study, at ages 4 to 8 years, children of women with low measured caffeine and paraxanthine during pregnancy were shorter than the children of women who consumed no caffeine during pregnancy, with increasing gaps in height in a historical cohort through age 8 years. There were no clear patterns of weight or body mass index changes.”

Shopping for ACA Health Insurance? Here’s What’s New This Year ACA plans’ open enrollment starts today. This article from KFF.org is an excellent summary of new features.

Cholera Outbreaks Surge Worldwide as Vaccine Supply Drains “A record number of cholera outbreaks around the globe, driven by droughts, floods and armed conflicts, has sickened hundreds of thousands of people and so severely strained the supply of cholera vaccines that global health agencies are rationing doses.
Outbreaks have been reported in the Caribbean, Africa, the Middle East and South Asia, putting the health of millions at risk and overwhelming fragile health systems.”

About health technology

 Pulse oximeters and their inaccuracies will get FDA scrutiny today. What took so long? ”Food and Drug Administration advisory committee Tuesday will take up the issue of whether pulse oximeters, the ubiquitous medical devices that became a mainstay for assessing patient oxygen levels during the Covid-19 pandemic, need to be regulated differently — or even completely reconceived — based on research showing the devices are less accurate in people with darker skin.
For many, the question is what took so long.
Studies dating back to 2005 show pulse oximeters tend to overestimate the amount of oxygen a patient with darker skin may actually have in their blood.”

About healthcare finance

JPMorgan creates healthcare venture capital team “JPMorgan has launched a healthcare venture capital team targeting the life sciences. 
The team, Life Sciences Private Capital, plans to invest in early- to later-stage healthcare companies and seeks to capitalize on innovation in areas such as genetic medicine, autoimmune diseases, cardiometabolic diseases and rare disorders, according to a Nov. 1 press release from JPMorgan.”

Today's News and Commentary

About Covid-19

 COVID DATA TRACKER WEEKLY REVIEW “As of October 26, 2022, the current 21-day average of weekly new cases (37,683) decreased 25.1% compared with the previous 21-day average (50,328). A total of 97,329,787 COVID-19 cases have been reported in the United States as of October 26, 2022.”

FDA says two studies showing omicron boosters weren’t much better than old Covid shots were too small to come to any conclusions “Dr. Peter Marks, head of the FDA’s vaccine division, said the new studies are small and subject to limitations. Data from larger well-controlled studies are coming soon, he added.”

About health insurance/insurers

 CMS rule change adds Medicare special enrollment periods “A CMS rule finalized Oct. 28 will reduce gaps in Medicare enrollment for new enrollees and adds special enrollment periods for extenuating circumstances. 
According to a news release from the agency, enrollees will begin receiving benefits the month after their enrollment, reducing gaps in coverage. 
The new rule adds special enrollment periods to allow individuals to sign up for Medicare coverage without a late penalty if they miss the initial enrollment period. 
The special enrollment periods apply to individuals if they were affected by a disaster, their employer or health plan misrepresented information about Medicare enrollment, they were incarcerated, or if they lose Medicaid coverage after the COVID-19 public health emergency ends. 
The rule also includes a new immunosuppressive drug benefit for Medicare recipients who have had a kidney transplant.”

About the public’s health

 Weekly U.S. Influenza Surveillance Report Key Points

  • Influenza activity continues to increase. Regions 4 (southeast) and 6 (south-central) are reporting the highest levels of flu activity.

  • The first influenza-associated pediatric death of the 2022-2023 season was reported this week.

  • CDC estimates that, so far this season, there have been at least 880,000 flu illnesses, 6,900 hospitalizations, and 360 deaths from flu.

  • The cumulative hospitalization rate in the FluSurv-NET system is higher than the rate observed in week 42 during previous seasons going back to 2010-2011.” 

About healthcare IT

 Patient preference survey finds drop in telehealth use, ER visits compared to 2021 “Stericycle Communication Solutions, a patient engagement solutions vendor, released the results of its third annual survey, which reached more than 1,000 adults. It found that 45% of respondents had used telehealth in the last year, compared to 78% in 2021 and 71% in 2020. It also found 93% of respondents had their last primary care visit in person. That is likely due to consumer preference, not a lack of telehealth availability, Stericycle’s senior vice president Matt Dickson told Fierce Healthcare.”

About health technology

 DA Roundup: October 28, 2022 “The FDA updated the list of Breakthrough Devices that have been authorized for marketing. The list includes 56 Breakthrough Devices that the FDA has authorized for marketing. Online metrics show the number of granted Breakthrough Device designations by fiscal year and by clinical panel, which totals 728 as of September 30, 2022.”

About healthcare finance

 Baxter reports $2.8 billion impairment charge on Hillrom acquisition “Baxter International, the Deerfield-based medical device company, revealed in its third-quarter earnings that it took a nearly $3 billion impairment charge related to its $10.5 billion Hillrom acquisition as inflation and supply chain constraints presented challenges for the business this year.
In its third-quarter earnings report, Baxter disclosed impairment charges of $2.8 billion on the acquisition of Hillrom, the maker of hospital beds and other tech-forward health care equipment. The acquisition was intended to help Baxter transform from a medical-products maker into a digital health care company.”

Today's News and Commentary

About Covid-19

 New Covid booster shots don't protect better against omicron BA.5, studies find “Scientists at Columbia University in New York found the new boosters did not produce a better antibody response against BA.5 than the first-generation vaccines, while a study by scientists at Harvard essentially came to the same conclusion…
The studies analysed samples from small groups, 21 people in the Columbia study and 18 in the Harvard study, who received the new boosters and compared them with individuals who received the old vaccine as their fourth dose.”
These studies are pre-publication and have not been peer reviewed.

‘Prime and Spike’ Nasal Vaccine Strategy Helps Combat COVID “A Yale-designed nasal vaccine can help bolster immune responses to COVID-19 in previously vaccinated animals and reduce viral transmission, Yale researchers report Oct. 27 in the journal Science.
The new vaccine approach developed by Yale researchers — which is known as ‘Prime and Spike’ — is designed to jumpstart immune response in the respiratory system, which is the first part of the body to be infected by the virus.
Intramuscular vaccine shots, which are what most people have received to protect against COVID-19 infection, provide a broad-based immune response throughout the body and help avert serious illness. However, that protection has tended to wane after about four months, leaving people susceptible to breakthrough infections and emerging variants.
The new ‘prime’ and ‘spike’ approach may help prevent breakthrough infections of vaccinated individuals by bolstering immune response within the mucosal lining of the respiratory tract, which are the first cells attacked by COVID-19.” 

About health insurance/insurers

 ACA's preventative care requirement under attack “Late Monday, plaintiffs in the case led by former Texas solicitor general Jonathan Mitchell filed a motion asking O'Connor to rule that under the ACA, insurers cannot be required to cover preventive services at no cost to patients.
The court should set aside the Preventive Services Task Force's A and B recommendations because the task force was never appointed by Congress, and thus lacks the authority to say which services insurers must cover.” 

Assessment of Spending for Patients Initiating Dialysis Care “This cohort study including 12 392 patients noted the initiation of dialysis care for privately insured patients with kidney failure was associated with significant increases in monthly spending from $5025 to $19 654. The differences in spending between patients receiving Medicare compared with private insurance were large: patients insured by Medicare had annual mean spending of $80 509 compared with $238 126 for privately insured patients in their first year of dialysis.”

OptumRx denies settlement in Ohio overcharging case “The Ohio Attorney General's Office said in an Oct. 25 news release the pharmacy benefit manager had agreed to pay that sum to settle allegations it overcharged the state's Bureau of Workers Compensation $15.8 million from 2015 to 2018. 
However, an Optum spokesperson told the news outlet a final agreement with the attorney general's office had not been reached and that the company continues to dispute the allegations.”

About pharma

 McKinsey reaches deal with U.S. local governments over opioids “Leading consulting firm McKinsey & Co has agreed to settle claims by hundreds of U.S. local governments and school districts around the country that it fueled an epidemic of opioid addiction through its work for bankrupt OxyContin maker Purdue Pharma LP and other drug companies.
The deal was disclosed in a court filing Wednesday evening in San Francisco federal court. Its terms were not made public, and McKinsey and a lawyer for the settling plaintiffs did not immediately respond to requests for comment.”

About the public’s health

 So far, this flu season is more severe than it has been in 13 years “Influenza is hitting the United States unusually early and hard, already hospitalizing a record number of people at this point in the season in more than a decade and underscoring the potential for a perilous winter of respiratory viruses, according to federal health data released Friday.” 

Annual report to the nation on the status of cancer, part 1: National cancer statistics “Cancer death rates continued to decline overall, for children, and for adolescents and young adults, and treatment advances have led to accelerated declines in death rates for several sites, such as lung and melanoma. The increases in incidence rates for several common cancers in part reflect changes in risk factors, screening test use, and diagnostic practice. Racial/ethnic differences exist in cancer incidence and mortality, highlighting the need to understand and address inequities. Population-based incidence and mortality data inform prevention, early detection, and treatment efforts to help reduce the cancer burden in the United States.”

Maternal consumption of ultra-processed foods and subsequent risk of offspring overweight or obesity: results from three prospective cohort studies “Maternal consumption of ultra-processed food during the child rearing period was associated with an increased risk of overweight or obesity in offspring, independent of maternal and offspring lifestyle risk factors. Further study is needed to confirm these findings and to understand the underlying biological mechanisms and environmental determinants.”

Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohort “The findings from this large scale prospective cohort study suggest a potential direct association between higher artificial sweetener consumption (especially aspartame, acesulfame potassium, and sucralose) and increased cardiovascular disease risk. Artificial sweeteners are present in thousands of food and beverage brands worldwide, however they remain a controversial topic and are currently being re-evaluated by the European Food Safety Authority, the World Health Organization, and other health agencies.”

About healthcare IT

 Association Between In-Person vs Telehealth Follow-up and Rates of Repeated Hospital Visits Among Patients Seen in the Emergency Department Question  Do the rates of repeated hospital visits differ between patients who were discharged following an emergency department (ED) visit and have in-person follow-up visits vs those who have telehealth follow-up visits?
Findings  In this cohort study that included 16 987 ED visits, telehealth follow-up was associated with 28.3 more repeated ED encounters and 10.6 more return hospital admissions per 1000 patients compared with in-person follow-up.” The results were severity adjusted.

Teladoc shares jump as Q3 losses narrow, revenue exceeds expectations amid turbulent year “Revenue during the most recent quarter rose 17% to $611 million from $522 million a year ago, slightly surpassing analysts' expectations of $609 million.
The biggest driver of that growth was BetterHelp, Teladoc's direct-to-consumer mental health brand. BetterHelp revenue rose 35% as compared to a year ago…”

Today's News and Commentary

About health insurance/insurers

 CMS to restrict Medicare Advantage TV ads, scrutinize brokers and agents amid high complaints “Starting next year, insurers will not be able to air any television ads for Medicare Advantage (MA) plans before getting approval from federal regulators. 
The new requirement is part of a larger effort by the Centers for Medicare & Medicaid Services (CMS) to address concerns in MA marketing practices. The new effort, announced in a memo released Oct. 19, comes as a Senate panel is also investigating how MA plans reach customers.”
Comment: The requirement is not new. These reviews were in place when Medicare managed care plans emerged in the 1980s.

White House touts 2023 ACA marketplace options as 'most competitive in history' “According to a CMS news release published Oct. 26, 92 percent of Americans will have three or more options to choose from on the marketplace. This number is up from 89 percent last year.”

Health Benefits In 2022: Premiums Remain Steady, Many Employers Report Limited Provider Networks For Behavioral Health From the new Kaiser Family Foundation annual report: ”In 2022 the average annual premium for family health insurance coverage was $22,463, which is similar to the $22,221 reported in 2021. On average, covered workers contributed $1,327 for single coverage and $6,106 for family coverage. Among covered workers enrolled in a plan with a general annual deductible, the average deductible for single coverage was $1,763. Almost half of large employers reported an increase from 2021 in the share of employees using mental health services. The 2022 survey asked employers about the breadth of their provider networks, especially for those using services for mental health and substance use disorders. Employers were less likely to report that their plan with the largest enrollment was very broad for mental health services than for providers overall. Fewer employers thought that their plan had a sufficient number of behavioral health providers versus primary care providers to provide timely access to enrollees.”

Molina's 61% net income boost in Q3 “Molina Healthcare reported a 61 percent increase in net income in the third quarter of 2022 compared to the same quarter in 2021, according to the company's Oct. 26 earnings report…
Molina raised its annual revenue earnings outlook by $500 million to $30.5 billion. The increase was attributed to third quarter outperformance, the Oct. 1 closure of its AgeWell acquisition and the expected impact of the extension of the COVID-19 Public Health Emergency through Jan. 11, 2023.”

Illinois fines Centene subsidiary $1.25M “Illinois insurance regulators are fining Centene subsidiary Celtic Insurance Co. $1.25 million for allegedly failing to cover mental health and addiction services at the same level as other medical issues…”
Comment: Nice to see this parity law is being enforced.

State-Based Marketplace Outreach Strategies for Boosting Health Plan Enrollment of the Uninsured From the Commonwealth Fund: “Key Findings: Most SBMs surveyed invested more in outreach during the open enrollment period for 2022 coverage compared to the previous open enrollment period. Nearly all SBMs extended the annual sign-up window into January. Advertising more-affordable plans under the ARPA helped bring in consumers who found coverage unaffordable under the former, less generous subsidy structure. SBMs conducted data-driven outreach and partnered with other entities to target the uninsured and those likely to need coverage, such as unemployment applicants. Culturally and linguistically appropriate outreach encouraged enrollment among underserved groups.”

About hospitals and healthcare systems

Community Health Systems logs $42M loss, 2.9% revenue decline for Q3 2022 “Community Health Systems (CHS) fell short of consensus estimates for the third quarter, reporting Wednesday evening a $42 million net loss ($0.32 per diluted share) and a 2.9% year-over-year decline in net operating revenues.
The Franklin, Tennessee-based hospital operator’s overall dip to $3.12 billion net operating revenue wasn’t helped by a 1.7% year-over-year increase in total operating costs and expenses ($2.82 billion).
CHS’ revenue decline was driven in part by reduced inpatient volumes. Admissions and same-store admissions decreased by 3.7% and 2.2%, respectively, while adjusted and same-store adjusted admissions increased 3.8% and 5.2%, respectively, the system reported.”

About pharma

 Drugmaker raises the price of an old chemo medicine tenfold amid persistent shortages “Amid sporadic shortages of a drug that is essential in preparing patients for lifesaving, cancer-fighting treatments, one manufacturer has returned to the market — but is selling its medicine for 10 to 20 times the prices offered by the only other companies with available supplies.
Over the past week, Areva Pharmaceuticals began marketing vials of fludarabine at a wholesale price of $2,736, a much steeper cost than the $272 charged for the same dosage by Fresenius Kabi and the $109 price tag from Teva Pharmaceuticals, according to data from IBM Micromedex, which gathers pricing data that is reported by manufacturers.”

About the public’s health

 FDA Denies Marketing of Logic’s Menthol E-Cigarette Products Following Determination They Do Not Meet Public Health Standard Yesterday the “U.S. Food and Drug Administration issued marketing denial orders (MDOs) for several e-cigarette products currently marketed by Logic Technology Development LLC (Logic). The currently marketed products include the Logic Pro Menthol e-Liquid Package and Logic Power Menthol e-Liquid Package. As a result, the company must not market or distribute these products in the United States or risk enforcement action by the FDA. These are the first menthol e-cigarette products to receive a marketing decision based on a full scientific review from the FDA.” 

About health technology

 CVS Health rolls out new home tests powered by health tech startup ixlayer “Ixlayer, a health tech company focused on lab testing, is now the platform for CVS Health home tests. 
Initial home sample collection kits will target vitamin D, Lyme disease, sexually transmitted infections and thyroid function with a plan to expand early next year, executives told Fierce Healthcare. In addition to the kits, users will have access to a platform that transmits test results and resources for understanding them.”

About healthcare finance

 Oracle looks to increase loan size to help fund Cerner acquisition “Software giant Oracle is in discussions with banks to increase the size of a $4.4 billion loan. The company will use the loan to refinance the debt used to fund its $28.4 billion acquisition of EHR company Cerner, Bloomberg reported Oct. 27.

Today's News and Commentary

About health insurance/insurers

 No Surprises Act: A Federal–State Partnership to Protect Consumers from Surprise Medical Bills From a study by the Commonwealth Fund: “Key Findings: To enforce protections under the No Surprises Act, most states are partnering with the federal government. In the majority of states, disputes over payments to out-of-network providers will be resolved by the federal independent dispute resolution system. Some state systems for resolving payments are more favorable to health care providers, potentially leading to higher awards and inflating health care costs. In many states, the No Surprises Act expands state protections against surprise bills, but some states offer additional protections. Consumer and provider education is important to guaranteeing effective protections.”

About hospitals and healthcare systems

 UHS reports lower profit amid staffing shortages “King of Prussia, Pa.-based Universal Health Services reported third-quarter net income of $182.8 million compared with $218.4 million in the same period last year amid labor shortages. The decrease in net income came even as revenues were up almost 6 percent in the quarter to total $3.34 billion.
Net income for the nine months ending Sept. 30 was down compared with the same period in 2021, totaling just over $500 million compared with $752.5 million in 2021. Revenues for the nine months in 2022 were again up on the same period last year, totaling $9.95 billion versus $9.4 billion.”

 About pharma

 OptumRx to pay $15M to settle Ohio overcharging allegations “UnitedHealth Group's OptumRx arm has agreed to pay $15 million to settle prescription drug overcharging allegations in Ohio. 
A lawsuit from Ohio's attorney general alleged that the pharmacy benefit manager overcharged the state's bureau of worker's compensation $15.8 million from 2015 to 2018, according to an Oct. 25 news release from the office.”

About the public’s health

 U.S. Preventive Services Task Force Issues Draft Recommendation on Screening for Skin Cancer “More research is needed to recommend for or against screening adolescents and adults without symptoms.” 

E-cigarettes may disrupt heart rhythm, hike risk of sudden cardiac arrest “Exposure to specific chemicals within e-cigarette liquids may trigger heart arrhythmias and electrical dysfunction -- cardiac effects similar to or worse than what conventional cigarettes may cause, a new study suggests.
The research from University of Louisville's Christina Lee Brown Envirome Institute found that exposure to e-cigarette aerosols can cause heart arrhythmias -- premature and skipped heart beats -- in mice models.”

About healthcare personnel

 Primary Care Health Professional Shortage Areas (HPSAs) Map and table of figures for each state from the Kaiser Family Foundation.

 About healthcare finance

 UnitedHealth sells $9B of bonds to support Change Healthcare purchase  “UnitedHealth Group has sold $9 billion of bonds that will help to refinance short-term debt the company took on to partially fund its purchase of Change Healthcare for $7.8 billion, Bloomberg reported Oct. 25.”

Today's News and Commentary

About Covid-19

 Association of Symptoms After COVID-19 Vaccination With Anti–SARS-CoV-2 Antibody Response in the Framingham Heart Study “In a sample of twice-vaccinated, older, community-dwelling US adults, self-reported systemic symptoms after SARS-CoV-2 mRNA vaccination were associated with greater antibody response vs local-only or no symptoms. These results agree with a previous report6 in US health care workers that showed higher postvaccination antibody measurements among those with significant symptoms after an mRNA vaccine.” 

About health insurance/insurers

 Express Scripts Announces Strategic Partnership with Centene to Unlock Greater Prescription Drug Savings “Beginning in January 2024, Express Scripts will manage pharmacy benefits for approximately 20 million Centene members. In addition to greater savings on prescription drugs, Centene customers will also have access to Express Scripts' extensive national network of retail pharmacies. Centene selected Express Scripts to administer pharmacy benefits after a competitive bidding process.”

Centene posts $738M in profit for Q3 as Medicare, Medicaid overperform “Its profit for the quarter was up from the $584 million it reported in the third quarter of 2021. Through the first three quarters of this year, Centene has earned $1.5 billion in profit, up from $748 million through three quarters in 2021, according to its earnings report released Tuesday morning.
Centene also beat the Street on revenue with $35.9 billion, up from $32.4 billion in the prior-year quarter. Through the first three quarters of 2022, Centene has brought in $109 billion in revenue, an increase from $93.4 billion through the first nine months of 2021….
Centene said its Medicare membership increased by 22%.”
About hospitals and healthcare systems

Healthgrades Award Recipient Hospitals FYI, the latest lists by state and specialities.

About pharma

 Amoxicillin Oral Presentations Information about the national Amoxicillin shortage.

About the public’s health

 Estimating the Prevalence of Dementia and Mild Cognitive Impairment in the US Question  What was the prevalence of dementia and mild cognitive impairment (MCI) in the US in 2016?
Findings  This nationally representative cross-sectional study found that approximately one-third of 3496 individuals 65 years and older had dementia or MCI. Prevalence rates were similar by sex but varied by age, education, and race and ethnicity.”

About healthcare IT

 Association of Video Gaming With Cognitive Performance Among Children “As part of the national Adolescent Brain Cognitive Development study and after controlling for confounding effects, results of this case-control study of 2217 children showed enhanced cognitive performance in children who played video games vs those who did not. Clear blood oxygen level–dependent signal differences were associated with video gaming in task-related brain regions during inhibition control and working memory.”

About health technology

 23andMe betting big on its genomic health service that integrates genetics with primary care “The company, which went public a year ago, has since amassed a huge database of genetic data based on its 13 million users. 23andMe has pivoted its strategy to leverage its trove of data for research and to make and sell its own therapies. The company also is expanding its core consumer genetic testing into a new business line called its genomic health service. 
Last October, the company announced plans to buy Lemonaid Health, a virtual care and pharmacy provider, to integrate its personalized genetics service more deeply into primary care. The strategy is to use that acquisition as a foundation for 23andMe's genomic health service, where customers can access their genetic information for preventive and personalized care, executives said a year ago. 
The key is to leverage Lemonaid Health's virtual care and online pharmacy capabilities to build out genetically driven telehealth and pharmacogenomic services.”

FDA clears Philips AI for making CT-like images from head and neck MRI scans “Philips has received clearance from the FDA for its artificial-intelligence-powered MRI platform geared toward head and neck cancers.
Dubbed MRCAT, for MR for Calculating ATtenuation, the application allows physicians to skip CT scans and use MRI machines as the primary or only imaging modality for planning radiotherapy in soft tissue tumors of the head and neck. 
The AI software—which creates images with CT-like density information derived from a single, high-resolution MR scan taking less than three minutes—can also be used to help treat cancers within the brain, pelvis and prostate by assisting with patient positioning and radiation dose calculations.”